PXD022755-1

PXD022755 is an original dataset announced via ProteomeXchange.

Title	SCF-Fbxo42 promotes synaptonemal complex assembly by downregulating PP2A-B56
Description	Meiosis creates genetic diversity by recombination and segregation of chromosomes. The synaptonemal complex assembles during meiotic prophase I and assists faithful exchanges between homologous chromosomes, but how its assembly/disassembly is regulated remains to be understood. Here we report how two major post-translational modifications, phosphorylation and ubiquitination, co-operate to promote synaptonemal complex assembly. We found that the ubiquitin ligase complex SCF is important for assembly and maintenance of the synaptonemal complex in Drosophila female meiosis. This function of SCF is mediated by two substrate-recognising F-box proteins, Slmb/βTrcp and Fbxo42. SCF-Fbxo42 downregulates the phosphatase subunit PP2A-B56, which is important for synaptonemal complex assembly and maintenance.
HostingRepository	PRIDE
AnnounceDate	2020-12-07
AnnouncementXML	Submission_2020-12-07_02:27:08.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Van Kelly
SpeciesList	scientific name: Drosophila melanogaster (Fruit fly); NCBI TaxID: 7227;
ModificationList	monohydroxylated residue; acetylated residue; iodoacetamide derivatized residue
Instrument	LTQ Orbitrap Elite

Revision	Datetime	Status	ChangeLog Entry
0	2020-11-26 00:21:52	ID requested
⏵ 1	2020-12-07 02:27:08	announced

Dataset with its publication pending

submitter keyword: Drosophila

Tony Ly
contact affiliation	Wellcome Centre for Cell Biology, University of Edinburgh
contact email	tony.ly@ed.ac.uk
lab head
Van Kelly
contact affiliation	University of Edinburgh
contact email	van.kelly@ed.ac.uk
dataset submitter

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PRIDE project URI

• PRIDE
  1. PXD022755
     1. Label: PRIDE project
     2. Name: SCF-Fbxo42 promotes synaptonemal complex assembly by downregulating PP2A-B56