PXD022731 is an
original dataset announced via ProteomeXchange.
Dataset Summary
Title | Dysfunction of CEP128 impairs spermatogenesis but not ciliogenesis in humans and mice |
Description | The centrosome is a conserved eukaryotic organelle essential for reproductive process, and centrosomal proteins (CEP) are necessary for composition of the centrosome. However, few CEPs have been genetically linked to fertility, and the related molecular mechanisms remains mysterious. Here, we identified a new CEP, CEP128, which is functional in spermatogenesis, fertilization and embryonic development in both humans and mice. The variants of CEP128/Cep128 could lead to aberrant centrosome structures of the sperm inducing to anomalies in sperm morphology, count as well as motility, and further result in male infertility, but did not grossly affect ciliogenesis. Mechanistically, both loss and up-regulation of CEP128 could cause suppressed expressions of the genes involved in the spermatogenesis and fertilization phase. Altogether, our findings unprecedentedly unveil a crucial role of CEP128 in male fertility and provides new insight into the function of CEPs in human disease. |
HostingRepository | PRIDE |
AnnounceDate | 2022-05-19 |
AnnouncementXML | Submission_2022-05-19_12:41:19.492.xml |
DigitalObjectIdentifier | |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | Jichang Huang |
SpeciesList | scientific name: Mus musculus (Mouse); NCBI TaxID: 10090; |
ModificationList | No PTMs are included in the dataset |
Instrument | Q Exactive HF |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
0 | 2020-11-25 04:24:13 | ID requested | |
⏵ 1 | 2022-05-19 12:41:20 | announced | |
Publication List
Zhang X, Wang L, Ma Y, Wang Y, Liu H, Liu M, Qin L, Li J, Jiang C, Zhang X, Shan X, Liu Y, Li J, Li Y, Zheng R, Sun Y, Sun J, Leng X, Liang Y, Zhang F, Jiang X, Yang Y, Shen Y, CEP128 is involved in spermatogenesis in humans and mice. Nat Commun, 13(1):1395(2022) [pubmed] |
Keyword List
submitter keyword: CEP128 |
infertility |
spermatogenesis |
centrosome |
Contact List
Ying Shen |
contact affiliation | West China Second University Hospital, Sichuan University |
contact email | yingcaishen01@163.com |
lab head | |
Jichang Huang |
contact affiliation | School of Life Sciences, Fudan University |
contact email | 14110700074@fudan.edu.cn |
dataset submitter | |
Full Dataset Link List
Dataset FTP location
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PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD022731
- Label: PRIDE project
- Name: Dysfunction of CEP128 impairs spermatogenesis but not ciliogenesis in humans and mice