PXD022716-2

PXD022716 is an original dataset announced via ProteomeXchange.

Title	Mapping novel biomarkers of liver injury by tissue proteomic analysis
Description	Liver damage is a dynamic process and evaluation of liver injury degree is the key step in disease diagnose. However, few common markers between different types of liver injury have been reported. Herein, we generate three liver injury mouse models including Con A induced, CCl4 injected and subjected BDL mouse model to simulate different types of liver damage in humans and then perform a Label free mass spectrometry to identify differently expressed proteins in liver tissues. Interestingly, two proteins, G3BP and ABCC6, are proposed to be biomarkers in liver injury. Overall, our study identifies two novel biomarkers of liver injury and they might be used as potential drug targets of liver damage researches.
HostingRepository	iProX
AnnounceDate	2020-11-25
AnnouncementXML	Submission_2023-03-01_23:12:24.566.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Bo Yang
SpeciesList	scientific name: Mus musculus; NCBI TaxID: 10090;
ModificationList	No PTMs are included in the dataset
Instrument	Q Exactive HF

Revision	Datetime	Status	ChangeLog Entry
0	2020-11-24 22:46:59	ID requested
1	2020-11-24 22:49:20	announced
⏵ 2	2023-03-01 23:12:25	announced	2023-03-02: Update publication information.

Yang B, Zhang J, Sun L, Huang T, Kong Y, Li L, Sun Z, Yin M, Li X, Mapping Novel Biomarkers of Liver Injury by Tissue Proteomic Analysis. ACS Omega, 6(10):7127-7138(2021) [pubmed]

submitter keyword: liver injury,biomarker,G3BP,ABCC6

Lei Li
contact affiliation	East China Normal University
contact email	lllkzj@163.com
lab head
Bo Yang
contact affiliation	East China Normal University
contact email	yangbo6674@163.com
dataset submitter

iProX dataset URI