PXD022708-1

PXD022708 is an original dataset announced via ProteomeXchange.

Title	Quantitative chemical proteomics of Leishmania mexicana
Description	We report the first systematic study of the effect of Hsp90 inhibition on the global protein synthesis in Leishmania parasites using an integrated chemical biology approach. Heat shock protein 90 (Hsp90) is a conserved molecular chaperone responsible for the folding of newly synthesised proteins. It is regarded as a master regulator of protein homeostasis of the cell, and its inhibition has been proposed to affect functions of a large array of its client proteins. We showed that the Hsp90 inhibition affects synthesis of many Leishmania proteins, with important chaperones and virulence factors showing an overall increased relative expression whilst many ribosomal proteins showing a down-regulation. This study defines the Leishmania parasite’s response to Hsp90 inhibition at its nascent global protein synthesis and provides a rich resource for future studies on Leishmania biology and antileishmanial drug development.
HostingRepository	PRIDE
AnnounceDate	2021-04-23
AnnouncementXML	Submission_2021-04-23_08:51:42.805.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Kalesh Karunakaran
SpeciesList	scientific name: Leishmania mexicana mexicana; NCBI TaxID: 44270;
ModificationList	No PTMs are included in the dataset
Instrument	TripleTOF 5600

Revision	Datetime	Status	ChangeLog Entry
0	2020-11-24 07:56:27	ID requested
⏵ 1	2021-04-23 08:51:43	announced

Dataset with its publication pending

submitter keyword: Leishmania, iTRAQ

Kalesh Karunakaran
contact affiliation	Department of Chemistry, Durham University, Durham, UK
contact email	kalesh.karunakaran@durham.ac.uk
lab head
Kalesh Karunakaran
contact affiliation	Durham University
contact email	kalesh.karunakaran@durham.ac.uk
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2021/04/PXD022708

PRIDE project URI

• PRIDE
  1. PXD022708
     1. Label: PRIDE project
     2. Name: Quantitative chemical proteomics of Leishmania mexicana