PXD022682 is an
original dataset announced via ProteomeXchange.
Dataset Summary
Title | Lipocalin 13 enhances insulin secretion but is dispensable for systemic metabolic control |
Description | Members of the lipocalin protein family serve as biomarkers for kidney disease and acute phase inflammatory reactions, and are under pre-clinical development for the diagnosis and therapy of allergies. However, none of the lipocalin family members has made the step into clinical development, mostly due to their complex biological activity and the lack of in-depth mechanistic knowledge. Here, we show that the hepatokine lipocalin 13 (LCN13) triggers glucose-dependent insulin secretion and cell proliferation of primary mouse islets. However, inhibition of endogenous LCN13 expression in lean mice did not alter glucose and lipid homeostasis. Enhanced hepatic secretion of LCN13 in either diet-induced or genetic obesity led to no discernable impact on systemic energy homeostasis, neither in preventive nor therapeutic setting. Of note, loss or forced LCN13 hepatic secretion did not trigger any compensatory regulation of related lipocalin family members. Together, these data are in stark contrast to the suggested gluco-regulatory and therapeutic role of LCN13 in obesity, and imply complex regulatory steps in LCN13 biology at the organismic level mitigating its principal insulinotropic effects. |
HostingRepository | PRIDE |
AnnounceDate | 2021-02-02 |
AnnouncementXML | Submission_2021-02-02_04:28:52.xml |
DigitalObjectIdentifier | |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | Christine von Toerne |
SpeciesList | scientific name: Mus musculus (Mouse); NCBI TaxID: 10090; |
ModificationList | No PTMs are included in the dataset |
Instrument | Q Exactive HF |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
0 | 2020-11-24 01:24:20 | ID requested | |
⏵ 1 | 2021-02-02 04:28:53 | announced | |
Publication List
Dataset with its publication pending |
Keyword List
submitter keyword: Hepatokine, Lipocalin 13, Metabolic diseases, Obesity, Type 2 diabetes |
Contact List
Stephan Herzig |
contact affiliation | Institute for Diabetes and Cancer (IDC), Helmholtz Centre Munich, German Research Center for Environmental Health, Neuherberg, Germany |
contact email | stephan.herzig@helmholtz-muenchen.de |
lab head | |
Christine von Toerne |
contact affiliation | Helmholtz Zentrum München |
contact email | vontoerne@helmholtz-muenchen.de |
dataset submitter | |
Full Dataset Link List
Dataset FTP location
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PRIDE project URI |
Repository Record List
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- PRIDE
- PXD022682
- Label: PRIDE project
- Name: Lipocalin 13 enhances insulin secretion but is dispensable for systemic metabolic control