PXD022613 is an
original dataset announced via ProteomeXchange.
Dataset Summary
Title | Characterization of biomarkers in Colorectal Cancer Liver Metastases as a prognostic tool |
Description | In this study we aimed to explore the molecular landscape of hepatic metastases and adjacent tissue in order to delineate a potential molecular signature that may be predictive for clinical benefit of CRCLM resection. Consecutive patients who underwent CRCLM resection between 2008 and 2015 at RMC, and for whom pathological specimen was available were included in the study. Cases were divided into two cohorts based on the interval between resection of liver metastases and disease recurrence- patients with less than 12-month interval were defined as ×´poor prognosis×´ (PP) and patients with more than 12 months as ×´good prognosis×´ (GP). Clinical data was retrieved from the medical records. Proteomic analysis was performed on the pathological bio specimen and correlated to demographics and clinical outcomes. Fifty-eight patients were included in the study. 29 in the GP cohort and 29 in the PP cohort. Proteomic analysis of the two-cohort revealed 99 proteins that were 38 differentially expressed, about a third of them associate with the extracellular matrix (ECM) pathways as the matrix metalloproteinases (MMPs). |
HostingRepository | PRIDE |
AnnounceDate | 2022-02-16 |
AnnouncementXML | Submission_2022-02-16_10:25:25.702.xml |
DigitalObjectIdentifier | |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | Tamar Ziv |
SpeciesList | scientific name: Homo sapiens (Human); NCBI TaxID: 9606; |
ModificationList | iodoacetamide derivatized residue |
Instrument | Q Exactive |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
0 | 2020-11-19 03:31:01 | ID requested | |
⏵ 1 | 2022-02-16 10:25:26 | announced | |
Publication List
Michal S, Tal GL, Gali P, Miki G, Elana B, Baroch B, Hanoch K, Irit BA, Riad H, Characterization of Biomarkers in Colorectal Cancer Liver Metastases as a Prognostic Tool. J Pers Med, 11(11):(2021) [pubmed] |
Keyword List
submitter keyword: Colorectal Cancer Liver Metastasis, Hepatic Surgery, Prognosis, Biomarkers, Molecular Signature. |
Contact List
Irit Ben-Aharon |
contact affiliation | Division of Oncology, Rambam Health Care Campus & Rappaport Faculty of Medicine, Technion, Haifa, Israel |
contact email | I_benaharon@rambam.health.gov.il |
lab head | |
Tamar Ziv |
contact affiliation | Technion |
contact email | tamarz@technion.ac.il |
dataset submitter | |
Full Dataset Link List
Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2022/02/PXD022613 |
PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD022613
- Label: PRIDE project
- Name: Characterization of biomarkers in Colorectal Cancer Liver Metastases as a prognostic tool