PXD022582 is an
original dataset announced via ProteomeXchange.
Dataset Summary
Title | MaxDIA enables highly sensitive and accurate library-based and library-free data-independent acquisition proteomics (DDA data) |
Description | MaxDIA is a universal platform for analyzing data-independent acquisition proteomics data within the MaxQuant software environment. Using spectral libraries, MaxDIA achieves cutting-edge proteome coverage with significantly better coefficients of variation in protein quantification than other software. MaxDIA is equipped with accurate false discovery rate estimates on both library-to-DIA match and protein levels, also when using whole-proteome predicted spectral libraries. This is the foundation of discovery DIA – a framework for the hypothesis-free analysis of DIA samples without library and with reliable FDR control. MaxDIA performs three- or four-dimensional feature detection of fragment data and scoring of matches is augmented by machine learning on the features of an identification. MaxDIA’s novel bootstrap-DIA workflow performs multiple rounds of matching with increasing quality of recalibration and stringency of matching to the library. Combining MaxDIA with two new technologies, BoxCar acquisition and trapped ion mobility spectrometry, both lead to deep and accurate proteome quantification. |
HostingRepository | PRIDE |
AnnounceDate | 2021-07-09 |
AnnouncementXML | Submission_2021-07-09_09:03:08.093.xml |
DigitalObjectIdentifier | |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | Yasset Perez-Riverol |
SpeciesList | scientific name: Escherichia coli; NCBI TaxID: 562; scientific name: Homo sapiens (Human); NCBI TaxID: 9606; scientific name: Saccharomyces cerevisiae (Baker's yeast); NCBI TaxID: 4932; |
ModificationList | acetylated residue; monohydroxylated residue; iodoacetamide derivatized residue |
Instrument | Q Exactive HF; QSTAR; 6410 Triple Quadrupole LC/MS |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
0 | 2020-11-17 05:30:52 | ID requested | |
⏵ 1 | 2021-07-09 09:03:08 | announced | |
2 | 2021-07-11 22:16:59 | announced | 2021-07-12: Updated publication reference for PubMed record(s): 34239088. |
Publication List
Dataset with its publication pending |
Keyword List
submitter keyword: MaxQuant, Benchmark |
Contact List
Jurgen Cox |
contact affiliation | Computational Systems Biochemistry Research Group, Max-Planck Institute of Biochemistry, Am Klopferspitz 18, 82152 Martinsried, Germany |
contact email | cox@biochem.mpg.de |
lab head | |
Yasset Perez-Riverol |
contact affiliation | EBI |
contact email | yperez@ebi.ac.uk |
dataset submitter | |
Full Dataset Link List
Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2021/07/PXD022582 |
PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD022582
- Label: PRIDE project
- Name: MaxDIA enables highly sensitive and accurate library-based and library-free data-independent acquisition proteomics (DDA data)