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PXD022527-1

PXD022527 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleQuantitative proteomics characterization of proteins modified by very long chain fatty acids (VLCFAs) under necroptosis
DescriptionNecroptosis is a caspase-independent form of regulated cell death that is characterized by membrane permeabilization and rupture. This membrane rupture is responsible for the inflammatory properties of necroptosis and is critical for disease states involving this process. In efforts to understand how lipids might contribute to necroptosis, we previously showed that saturated very long chain fatty acids (VLCFAs) are functionally involved in this process, potentially through protein fatty acylation. Here we define the scope of protein acylation by saturated VLCFAs during necroptosis using a clickable lipid analog and IonStar quantitative proteomics.As a result, a total of 1672 proteins were quantified with high precision and no missing data across samples in the same condition. 1267 were detected with higher abundances in control cells and 405 were detected with higher abundance in necroptotic conditions.
HostingRepositoryPRIDE
AnnounceDate2021-05-25
AnnouncementXMLSubmission_2021-05-25_06:46:43.389.xml
DigitalObjectIdentifier
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterShichen Shen
SpeciesList scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationListacetylated residue; monohydroxylated residue; iodoacetamide derivatized residue
InstrumentOrbitrap Fusion Lumos
Dataset History
RevisionDatetimeStatusChangeLog Entry
02020-11-13 08:00:23ID requested
12021-05-25 06:46:43announced
22021-05-25 22:08:46announced2021-05-26: Updated project metadata.
Publication List
10.1016/J.CHEMBIOL.2021.03.012;
Keyword List
submitter keyword: IonStar proteomics acylation necroptosis
Contact List
Jun Qu
contact affiliationDepartment of Pharmaceutical Sciences School of Pharmacy and Pharmaceutical Sciences University at Buffalo, State University of New York
contact emailjunqu@buffalo.edu
lab head
Shichen Shen
contact affiliationUniversity at Buffalo
contact emailshichens@buffalo.edu
dataset submitter
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Dataset FTP location
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PRIDE project URI
Repository Record List
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