PXD022523-2

PXD022523 is an original dataset announced via ProteomeXchange.

Title	Delayed induction of type I and III interferons enhances nasal epithelial permissiveness to SARS-CoV-2
Description	We provide the first comprehensive analysis of nasal cell responses to SARS-COV-2 using single cell transcriptomics and proteomics. The immune response to SARS-CoV-2 is dominated by a delayed type I and III IFN response, which is too slow to contain viral replication. Cells transitioning from secretory to ciliated states are highly permissive to SARS-CoV-2, whereas goblet cells are relatively resistant. Cell-type differences in the production and response to IFN-I/III correlate with permissiveness. Pre-treatment with recombinant IFNs potently restricts SARS-CoV-2. Nasal delivery of recombinant IFNs is a promising prophylactic strategy for SARS-CoV-2
HostingRepository	PRIDE
AnnounceDate	2023-04-11
AnnouncementXML	Submission_2023-04-11_06:26:56.952.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	MatthiasTrost
SpeciesList	scientific name: Severe acute respiratory syndrome coronavirus 2; NCBI TaxID: NCBITaxon:2697049; scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	acetylated residue; iodoacetamide derivatized residue
Instrument	Orbitrap Fusion Lumos

Revision	Datetime	Status	ChangeLog Entry
0	2020-11-13 07:10:52	ID requested
1	2021-05-25 08:02:59	announced
⏵ 2	2023-04-11 06:26:57	announced	2023-04-11: Updated project metadata.

Hatton CF, Botting RA, Due, ñ, as ME, Haq IJ, Verdon B, Thompson BJ, Spegarova JS, Gothe F, Stephenson E, Gardner AI, Murphy S, Scott J, Garnett JP, Carrie S, Powell J, Khan CMA, Huang L, Hussain R, Coxhead J, Davey T, Simpson AJ, Haniffa M, Hambleton S, Brodlie M, Ward C, Trost M, Reynolds G, Duncan CJA, Delayed induction of type I and III interferons mediates nasal epithelial cell permissiveness to SARS-CoV-2. Nat Commun, 12(1):7092(2021) [pubmed]

ProteomeXchange project tag: Covid-19

submitter keyword: SARS-CoV-2, human, nasal

MatthiasTrost
contact affiliation	Newcastle University Biosciences Institute, Newcastle University, Newcastle upon Tyne, UK
contact email	matthias.trost@ncl.ac.uk
lab head
MatthiasTrost
contact affiliation	Newcastle University
contact email	matthias.trost@ncl.ac.uk
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2021/05/PXD022523

PRIDE project URI

• PRIDE
  1. PXD022523
     1. Label: PRIDE project
     2. Name: Delayed induction of type I and III interferons enhances nasal epithelial permissiveness to SARS-CoV-2