PXD022417-1
PXD022417 is an original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Dysregulation of the complement and coagulation cascade in treated schizophrenia and bipolar disorder patients |
| Description | A better understanding of the proteomic profile after bipolar disorder (BD) and schizophrenia (SCZ) treatment, through monitoring its progression, may assist the development of novel therapeutic strategies with the ability to reduce or control possible side effects. In this study, proteomics analysis employing liquid chromatography coupled to mass spectrometry (LC-MS) and bioinformatic tools were applied to identify differentially expressed proteins in serum of treated BD and SCZ patients. In total, 10 BD patients, 10 SCZ patients, and 14 healthy participants were included. From 25 serum proteins significantly altered (> 1.5- fold change), 8 were down-regulated in the BD group, while 7 proteins were up- regulated and 2 down-regulated in SCZ group when compared against healthy controls. Bioinformatics analysis based on these 25 proteins validated two main altered pathways previously described in the literature; furthermore, it revealed that opposite expressions of the complement and coagulation cascades were the most significant biological processes involved in these pathologies. Associations of disease-proteins and pathways suggest therapeutic intervention or prevention of comorbidities risks for BD and SCZ. Further validation and investigation are required to define whether there is correlation between complement and coagulation cascade expression for both diseases and cardiovascular diseases. |
| HostingRepository | MassIVE |
| AnnounceDate | 2022-06-22 |
| AnnouncementXML | Submission_2022-06-22_09:26:21.048.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Non peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Elisa Casta�eda |
| SpeciesList | scientific name: Homo sapiens; common name: human; NCBI TaxID: 9606; |
| ModificationList | Carbamidomethyl; Oxidation |
| Instrument | LTQ Orbitrap Elite |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|---|---|---|
| 0 | 2020-11-07 16:35:54 | ID requested | |
| ⏵ 1 | 2022-06-22 09:26:21 | announced |
Publication List
| no publication |
Keyword List
| submitter keyword: Shotgun Proteomics, Label-free, MaxQuant, Bipolar disorder, Schizophrenia |
Contact List
| Alessandra Sussulini | |
|---|---|
| contact affiliation | Universidade Estadual de Campinas |
| contact email | sussulini@unicamp.br |
| lab head | |
| Elisa Casta�eda | |
| contact affiliation | Unicamp |
| contact email | elisacsan@gmail.com |
| dataset submitter | |
Full Dataset Link List
| MassIVE dataset URI |
| Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://massive.ucsd.edu/MSV000086425/ |
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