PXD022314-2

PXD022314 is an original dataset announced via ProteomeXchange.

Title	Low-expressing synucleinopathy mouse models based on oligomer formation and C-terminal truncation of α-synuclein
Description	Two mouse models were developed that expressed mutated human alpha synuclein under the control of endogenous murine αSyn (mαSyn) regulatory regions. The expression of the mαSyn was thereby abolished. The genetically ingeneered mice expressed either human αSyn (hαSyn) with a C-terminal deletion ending hαSyn at amino acid 119 or hαSyn with 3 alanine to proline substitutions at residues 30, 56, and 76. Here we tested the expression of different αSyn variants in the hippocampus of respective mouse models and their parental lines.
HostingRepository	PRIDE
AnnounceDate	2024-10-22
AnnouncementXML	Submission_2024-10-22_05:22:26.258.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Ivan Silbern
SpeciesList	scientific name: Mus musculus (Mouse); NCBI TaxID: 10090; scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	No PTMs are included in the dataset
Instrument	TSQ Quantiva

Revision	Datetime	Status	ChangeLog Entry
0	2020-11-03 05:30:42	ID requested
1	2021-05-27 21:55:32	announced
⏵ 2	2024-10-22 05:22:26	announced	2024-10-22: Updated project metadata.

Dataset with its publication pending

submitter keyword: α-synuclein mutants, neuroinflammation, transgenic mouse, truncation, motor impairment, oligomerization, Parkinson’s disease, olfaction

Prof. Dr. Henning Urlaub
contact affiliation	1. Institute of Clinical Chemistry, University Medical Center Goettingen, Goettingen, Germany; 2. Bioanalytical Mass Spectrometry Group, Max Planck Institute for Biophysical Chemistry, Goettingen, Germany
contact email	henning.urlaub@mpibpc.mpg.de
lab head
Ivan Silbern
contact affiliation	MPI Biophysical Chemistry
contact email	ivansilbern@gmail.com
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2021/05/PXD022314

PRIDE project URI

• PRIDE
  1. PXD022314
     1. Label: PRIDE project
     2. Name: Low-expressing synucleinopathy mouse models based on oligomer formation and C-terminal truncation of α-synuclein