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PXD022189-1

PXD022189 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleLabel-Free LC-MS/MS Proteomic Analysis of Urinary Identification in Diabetic Vascular Dementia
DescriptionObjective: The aim of this study was to identify novel diagnostic biomarkers of diabetic vascular dementia (DVD) and unraveling the underlying mechanisms using mass spectrometry (MS). Methods: Label-Free LC-MS/MS proteomics analysis was applied to urine samples from four groups including 14 vascular dementia CC(VD), 22 type 2 diabetes mellitus (T2DM), 12 DVD, 21 Normal Control (NC). Searching the MS data by Proteome Discoverer software, protein abundances were analyzed qualitatively and quantitatively and compared between these groups. Combining bioinformatics analysis using GO, pathway crosstalk analysis using KEGG, PPI network analysis using STRING and literature searching, the differentially expressed proteins (DEPs) of DVD can be comprehensively judged and were further quantified by receiver operating characteristic (ROC) curve methods. Results: The proteomic findings showed quantitative changes in DVD was compared to NC, T2DM, and VD groups; among 7,527 identified urine proteins, 1222, 1152, and 1180 of the proteins displayed quantitative changes unique to DVD vs NC, T2DM, and VD, respectively, including 481 overlapped common DEPs. Then 9 unique proteins and 2 composite markers (CM) were confirmed by a ROC curve method. Conclusion: This study provided a novel insight into the potential pathogenesis of DVD and elucidated a method for the earlier detection.
HostingRepositoryPRIDE
AnnounceDate2021-01-14
AnnouncementXMLSubmission_2021-01-13_23:58:31.xml
DigitalObjectIdentifier
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterYi Zeng
SpeciesList scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationListNo PTMs are included in the dataset
InstrumentQ Exactive HF; Q Exactive
Dataset History
RevisionDatetimeStatusChangeLog Entry
02020-10-26 07:53:46ID requested
12021-01-13 23:58:31announced
Publication List
Dataset with its publication pending
Keyword List
submitter keyword: diabetes, vascular dementia, biomarkers, protein, urine, proteomics
Contact List
Yi Zeng
contact affiliationsecond xiangya hospital central south university
contact emailzengyi_xyneuro@csu.edu.cn
lab head
Yi Zeng
contact affiliationSecond Xiangya Hospital, Central South University
contact emailzengyi_xyneuro@csu.edu.cn
dataset submitter
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Dataset FTP location
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