PXD022180-1

PXD022180 is an original dataset announced via ProteomeXchange.

Title	Mytho, An Uncharacterized Gene that Controls Longevity and WIPI2-dependent Autophagy
Description	The identification of genes that confer either extension of life span or accelerate age-related decline was a step forward in our understanding the mechanisms of senescence and revealed that aging process is partially controlled by genetics and transcriptional programs. Here we identified that the unknown DNA sequence c16orf70 encodes for a protein, named Mytho, that controls life span. Mytho is conserved from worms to humans and is upregulated in aged mice and elderly people. Deletion of the ortholog Mytho gene in C. elegans dramatically shortened life-span and decreased animal survival upon exposure to oxidative stress. Mechanistically, MYTHO is required for autophagy because it acts as scaffold to recruit and assemble the conjugation system at the phagophore assembly site (PAS). We conclude that Mytho is a transcriptionally regulated initiator of autophagy that is central in promoting stress resistance to ensure organism longevity.
HostingRepository	PRIDE
AnnounceDate	2024-07-02
AnnouncementXML	Submission_2024-07-02_10:45:17.531.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	marco sandri
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	No PTMs are included in the dataset
Instrument	Q Exactive HF

Revision	Datetime	Status	ChangeLog Entry
0	2020-10-26 02:49:32	ID requested
⏵ 1	2024-07-02 10:45:17	announced
2	2024-10-22 06:48:16	announced	2024-10-22: Updated project metadata.

10.1172/JCI165814;

submitter keyword: WIPI2, autophagy, longevity,Mytho

Marco Sandri
contact affiliation	Department of Biomedical Science, University of Padova, via U. Bassi 58b, 35121 Padova, Italy. Venetian Institute of Molecular Medicine, via Orus 2, 35129 Padova, Italy Myology Center, University of Padova, via G. Colombo 3, 35100 Padova, Italy. Department of Medicine, McGill University, Montreal, Canada. Department of Pharmacology & Therapeutics, College of Medicine, University of Florida, USA.
contact email	marco.sandri@unipd.it
lab head
marco sandri
contact affiliation	Department of Biomedical Sciences, University or Padova
contact email	marco.sandri@unipd.it
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2024/07/PXD022180

PRIDE project URI

• PRIDE
  1. PXD022180
     1. Label: PRIDE project
     2. Name: Mytho, An Uncharacterized Gene that Controls Longevity and WIPI2-dependent Autophagy