PXD022005-1

PXD022005 is an original dataset announced via ProteomeXchange.

Title	Human prostate cancer and Lysine succinylation
Description	: Prostate cancer (PCa) is the most commonly diagnosed genital cancer in men worldwide. Among patients who developed advanced PCa, 80% suffered from bone metastasis, with a sharp drop in the survival rate. Using quantitative global succinylome analysis, we characterized a significant increase of lysine 118 succinylation (K118su) of lactate dehydrogenase A (LDHA), which plays a role in increasing LDHA activity. As a substrate of SIRT5, LDHA-K118su significantly increased the migration and invasion of PCa cells and LDHA activity in PCa patients.
HostingRepository	PRIDE
AnnounceDate	2023-06-21
AnnouncementXML	Submission_2023-06-20_22:58:58.722.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Oh KwangKwon
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	succinylated residue
Instrument	LTQ Orbitrap Velos

Revision	Datetime	Status	ChangeLog Entry
0	2020-10-15 04:23:00	ID requested
⏵ 1	2023-06-20 22:58:59	announced
2	2023-11-14 09:01:23	announced	2023-11-14: Updated project metadata.

Kwon OK, Bang IH, Choi SY, Jeon JM, Na AY, Gao Y, Cho SS, Ki SH, Choe Y, Lee JN, Ha YS, Bae EJ, Kwon TG, Park BH, Lee S, LDHA Desuccinylase Sirtuin 5 as A Novel Cancer Metastatic Stimulator in Aggressive Prostate Cancer. Genomics Proteomics Bioinformatics, 21(1):177-189(2023) [pubmed]

submitter keyword: prostate cancer, Lysine succinylation, metastasis

SangkyuLee
contact affiliation	College of Pharmacy, Kyungpook National University
contact email	sangkyu@knu.ac.kr
lab head
Oh KwangKwon
contact affiliation	Kyungpook National University
contact email	kok0100@nate.com
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2023/06/PXD022005

PRIDE project URI

• PRIDE
  1. PXD022005
     1. Label: PRIDE project
     2. Name: Human prostate cancer and Lysine succinylation