PXD021851-2

PXD021851 is an original dataset announced via ProteomeXchange.

Dataset Summary

Title	Periodontal pathogen induces entero-hepatic metabolic derangements in type 2 diabetic mouse model
Description	This is the first report of the metabolic and metaproteomic integrated changes in the gut and liver by the swallowed periodontopathogen. Periodontal disease pathogen Porphyromonas gingivalis are observed in faeces as peptides level in proteomic analysis and make changes in bowel microbial composition in db/db mouse. Orally Periodontal disease pathogen throwing as experimental periodontal disease model make gluconeogenesis in db/db mouse liver and hyperglycemia. Multi-omics analysis reveal Pg decreasing in energy metabolism and glucagon store in db/db mouse liver. These findings suggest that periodontal treatment improving oral microbiota can make diabetic hyperglycemia ameliorate in liver and support these diabetes treatments credibly.
HostingRepository	jPOST
AnnounceDate	2021-09-21
AnnouncementXML	Submission_2022-09-18_03:27:16.526.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Naoyuki Sugiyama
SpeciesList	scientific name: cellular organisms; NCBI TaxID: 131567; scientific name: cellular organisms; NCBI TaxID: 131567;
ModificationList	L-methionine sulfoxide; S-carboxamidomethyl-L-cysteine; TMT6plex reporter+balance reagent N-acylated residue; TMT6plex reporter+balance reagent acylated N-terminal; alpha-amino dimethylated residue; N6,N6-dimethyl-L-lysine; unknown modification; unknown modification
Instrument	Orbitrap Fusion Lumos; Q Exactive

Dataset History

Revision	Datetime	Status	ChangeLog Entry
0	2020-10-05 17:47:06	ID requested
1	2021-09-21 00:08:18	announced
⏵ 2	2022-09-18 03:27:17	announced	2022-09-18: Updated FTP location.

Publication List

Kashiwagi Y, Aburaya S, Sugiyama N, Narukawa Y, Sakamoto Y, Takahashi M, Uemura H, Yamashita R, Tominaga S, Hayashi S, Nozaki T, Yamada S, Izumi Y, Kashiwagi A, Bamba T, Ishihama Y, Murakami S, Porphyromonas gingivalis induces entero-hepatic metabolic derangements with alteration of gut microbiota in a type 2 diabetes mouse model. Sci Rep, 11(1):18398(2021) [pubmed]

Kashiwagi Y, Aburaya S, Sugiyama N, Narukawa Y, Sakamoto Y, Takahashi M, Uemura H, Yamashita R, Tominaga S, Hayashi S, Nozaki T, Yamada S, Izumi Y, Kashiwagi A, Bamba T, Ishihama Y, Murakami S, Porphyromonas gingivalis induces entero-hepatic metabolic derangements with alteration of gut microbiota in a type 2 diabetes mouse model. Sci Rep, 11(1):18398(2021) [pubmed]

Keyword List

submitter keyword: metaproteome, mouse liver, feces

submitter keyword: metaproteome, mouse liver, feces

Contact List

Shinya Murakami
lab head
Naoyuki Sugiyama
contact affiliation	Kyoto University
dataset submitter

Full Dataset Link List

jPOST dataset URI
Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.jpostdb.org/JPST000974/

jPOST dataset URI

Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.jpostdb.org/JPST000974/