PXD021793-1

PXD021793 is an original dataset announced via ProteomeXchange.

Title	Unbiased label-free quantitative proteomics of Amyotrophic lateral sclerosis (ALS) mutations in CCNF reveals activation of the apoptosis pathway
Description	The past 10 years has seen a rapid acceleration in the discovery of new genetic causes of ALS, with more than 20 putative ALS-causing genes now cited. These genes express proteins that cover a diverse range of molecular functions, including free radical scavenging (cf SOD1), regulation of RNA homeostasis (cf TDP-43, FUS), and protein degradation through the ubiquitin-proteasome system (cf ubiquilin-2, Cyclin F) and autophagy. However, not all of the reported ALS-causing genes have been replicated in subsequent genetic studies – raising significant question marks on the true validity of some putative ALS genes (such as profilin and angiogenin). Furthermore, it still remains unclear what common molecular mechanisms or pathways link these diverse genes/proteins, such that defects in these individual proteins ultimately converge to cause ALS. This study seeks to develop an innovative pipeline to start to address some of these questions.
HostingRepository	PRIDE
AnnounceDate	2021-03-31
AnnouncementXML	Submission_2021-03-30_16:56:54.500.xml
DigitalObjectIdentifier	https://dx.doi.org/10.6019/PXD021793
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Supported dataset by repository
PrimarySubmitter	Albert Lee
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	ubiquitination signature dipeptidyl lysine; monohydroxylated residue; iodoacetamide derivatized residue
Instrument	Q Exactive

Revision	Datetime	Status	ChangeLog Entry
0	2020-10-02 04:16:59	ID requested
⏵ 1	2021-03-30 16:56:54	announced

Dataset with its publication pending

submitter keyword: amytrophic lateral sclerosis, proteogenomics, ccnf, apoptosis, neurodegeneration, iPSCs

Albert Lee
contact affiliation	Centre for MND Research, Department of Biomedical Sciences, Faculty of Medicine, Health and Human Sciences, Macquarie University, North Ryde, NSW, 209, Australia
contact email	albert.lee@mq.edu.au
lab head
Albert Lee
contact affiliation	Macquarie University
contact email	albert.lee@mq.edu.au
dataset submitter

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PRIDE project URI

• PRIDE
  1. PXD021793
     1. Label: PRIDE project
     2. Name: Unbiased label-free quantitative proteomics of Amyotrophic lateral sclerosis (ALS) mutations in CCNF reveals activation of the apoptosis pathway