PXD021788-1

PXD021788 is an original dataset announced via ProteomeXchange.

Title	Human vitreous TMT labelled LC-MS/MS
Description	Proliferative diabetic retinopathy (PDR) is a severe complication of diabetes and can cause blindness. However, the available therapeutic modalities to PDR have unsatisfactory efficacies and incur adverse effects, which is due to the paucity in the understanding of pathogenic mechanisms responsible for the disease. In this study, tandem mass tag labeling technology combined with liquid chromatography and tandem mass spectrometry were utilized to identify differentially expressed proteins in vitreous humor of patients with rhegmatogenous retinal detachment and PDR.
HostingRepository	PRIDE
AnnounceDate	2020-12-18
AnnouncementXML	Submission_2020-12-18_02:59:36.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Yan Zhang
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	No PTMs are included in the dataset
Instrument	LTQ Orbitrap Elite

Revision	Datetime	Status	ChangeLog Entry
0	2020-10-02 04:14:17	ID requested
⏵ 1	2020-12-18 02:59:37	announced

Niu R, Wang J, Geng C, Li Y, Dong L, Liu L, Chang Y, Shen J, Nie Z, Zhang Y, Hu B, Tandem mass tag-based proteomic analysis reveals cathepsin-mediated anti-autophagic and pro-apoptotic effects under proliferative diabetic retinopathy. Aging (Albany NY), 13(1):973-990(2020) [pubmed]

submitter keyword: proliferative diabetic retinopathy, LC-MS/MS, proteomics, CTSB, CTSD

Yan Zhang
contact affiliation	Eye Institute and School of Optometry, Tianjin Medical University Eye Hospital,
contact email	yanzhang04@tmu.edu.cn
lab head
Yan Zhang
contact affiliation	Tianjin Medical University Eye Hospital, Eye Institute and School of Optometry
contact email	yanzhang04@tmu.edu.cn
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2020/12/PXD021788

PRIDE project URI

• PRIDE
  1. PXD021788
     1. Label: PRIDE project
     2. Name: Human vitreous TMT labelled LC-MS/MS