PXD021733-1

PXD021733 is an original dataset announced via ProteomeXchange.

Title	VWCE inhibited the proliferation, migration, invasion, and chemoresistance of the breast cancer cell lines
Description	Breast cancer remains a leading cause of cancer-related death, for which the majority of deaths result from metastases. Von Willebrand factor C and EGF domain (VWCE) is a member of the Von Willebrand factor (VWF) gene family; however, its function, regulatory mechanism, and clinical value in breast cancer remain unclear. In the present study, we sought to elucidate the role of VWCE in breast cancer metastasis. We examined the expression of VWCE in breast cancer tissues and normal control tissues of 50 breast cancer patients. We found that VWCE expression was downregulated in breast cancer cells and tissues compared to normal breast epithelial cells or the adjacent normal tissues. To explore the role of VWCE in human breast cancer development, we introduced a VWCE-overexpressing or control lentiviral vector into the breast cancer MDA-MB-453 and MDA-MB-231 lines in vitro. The overexpression of VWCE inhibited the proliferation, migration, invasion, and chemoresistance of the breast cancer cell lines. More import
HostingRepository	iProX
AnnounceDate	2020-09-29
AnnouncementXML	Submission_2020-10-20_18:35:44.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Dan Zhang
SpeciesList	scientific name: Homo sapiens; NCBI TaxID: 9606;
ModificationList	No PTMs are included in the dataset
Instrument	Q Exactive HF

Revision	Datetime	Status	ChangeLog Entry
0	2020-09-29 00:55:20	ID requested
⏵ 1	2020-10-20 18:35:44	announced

Dataset with its publication pending

submitter keyword: breast cancer cells, VWCE,tumor suppressor,WDR1,metastasis

Ni Xie
contact affiliation	The First Affiliated Hospital of Shenzhen University,Health Science Center
contact email	xn100@szu.edu.cn
lab head
Dan Zhang
contact affiliation	Shenzhen Second People’s Hospital
contact email	13762470784@163.com
dataset submitter

iProX dataset URI