PXD021692-1

PXD021692 is an original dataset announced via ProteomeXchange.

Title	Ciprofloxacin-resistant Staphylococcus aureus keeps resistance and virulence in Iron-restricted Condition
Description	In summary, this study shows advantages of the CIP-R in the survival, drug resistance and virulence in iron restricted condition. DIA-based proteomics study combined with biochemical validation showed that CIP-R saves the energy by storing the glucose and increases the cell wall synthesis. Moreover, CIP-R more stable in many metabolisms than CIP-S due to the up-regulation them during long term pressure of antibiotics, which could keep the survival ability of CIP-R. These advantages not possessed by CIP-S, makes the CIP-R easier to reside in host and keep resistance ability. Importantly, CIP-R exhibited an increased virulence under iron limitation condition which is completely different from sensitive bacteria. The novel adapting countermeasures reveal the reason why the CIP-R were harder to eliminate by human immunity system and help people to find out a new method for the CIP-R treatment.
HostingRepository	PRIDE
AnnounceDate	2021-03-31
AnnouncementXML	Submission_2021-03-31_05:13:23.278.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	YingShan DONG
SpeciesList	scientific name: Staphylococcus aureus; NCBI TaxID: 1280;
ModificationList	No PTMs are included in the dataset
Instrument	Orbitrap Fusion Lumos

Revision	Datetime	Status	ChangeLog Entry
0	2020-09-25 07:37:24	ID requested
⏵ 1	2021-03-31 05:13:23	announced
2	2021-04-22 00:08:54	announced	2021-04-22: Updated project metadata.

Dataset with its publication pending

submitter keyword: Staphylococcus aureus, iron-restricted, proteomics, virulence

Xuesong SUN
contact affiliation	Key Laboratory of Functional Protein Research of Guangdong Higher Education Institutes, Institute of Life and Health Engineering, College of Life Science and Technology, Jinan University, Guangzhou 510632, China
contact email	tsunxs@jnu.edu.cn
lab head
YingShan DONG
contact affiliation	Key Laboratory of Functional Protein Research of Guangdong Higher Education Institutes, Institute of Life and Health Engineering, College of Life Science and Technology, Jinan University, Guangzhou 510632, China
contact email	503890477@qq.com
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2021/03/PXD021692

PRIDE project URI

• PRIDE
  1. PXD021692
     1. Label: PRIDE project
     2. Name: Ciprofloxacin-resistant Staphylococcus aureus keeps resistance and virulence in Iron-restricted Condition