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PXD021569-1

PXD021569 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleSex-specific effects of in vitro fertilization on adult metabolic phenotypes and hepatic transcriptomic and proteomic pathways in mouse
DescriptionAlthough in vitro fertilization (IVF) is associated with adverse perinatal outcomes, an increasing concern is the long-term health implications. We augmented our IVF mouse model to longitudinally investigate cardiometabolic outcomes in offspring from optimal neonatal litter sizes. We found that IVF-conceived females had higher body weight and cholesterol levels compared to naturally-conceived females, whereas IVF-conceived males had higher levels of triglycerides and insulin, and increased body fat composition. Through transcriptomics and proteomics of adult liver, we identified sexually-dimorphic dysregulation of the sterol regulatory element binding protein (SREBP) pathways that are associated with the sex-specific phenotypes. We also found that global loss of DNA methylation in placenta was linked to higher cholesterol levels in IVF-conceived females. Our findings indicate that IVF procedures have long-lasting sex-specific effects on metabolic health of offspring and lay the foundation to utilize the placenta as a predictor of long-term outcomes.
HostingRepositoryMassIVE
AnnounceDate2021-03-16
AnnouncementXMLSubmission_2021-03-16_14:47:43.429.xml
DigitalObjectIdentifier
ReviewLevelNon peer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterJosue Baeza
SpeciesList scientific name: Mus musculus; common name: house mouse; NCBI TaxID: 10090;
ModificationListCarbamidomethyl
Instrumentinstrument model
Dataset History
RevisionDatetimeStatusChangeLog Entry
02020-09-18 14:29:54ID requested
12021-03-16 14:47:43announced
Publication List
no publication
Keyword List
submitter keyword: DIA, Assisted Reproductive Technologies, developmental origins of health and disease (DOHaD)
Contact List
Bartolomei, Marisa
contact affiliationUniversity of Pennsylvania
contact emailbartolom@pennmedicine.upenn.edu
lab head
Josue Baeza
contact affiliationUniversity of Pennsylvania
contact emailbaeza@pennmedicine.upenn.edu
dataset submitter
Full Dataset Link List
MassIVE dataset URI
Dataset FTP location
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