PXD021569-1

PXD021569 is an original dataset announced via ProteomeXchange.

Dataset Summary

Title	Sex-specific effects of in vitro fertilization on adult metabolic phenotypes and hepatic transcriptomic and proteomic pathways in mouse
Description	Although in vitro fertilization (IVF) is associated with adverse perinatal outcomes, an increasing concern is the long-term health implications. We augmented our IVF mouse model to longitudinally investigate cardiometabolic outcomes in offspring from optimal neonatal litter sizes. We found that IVF-conceived females had higher body weight and cholesterol levels compared to naturally-conceived females, whereas IVF-conceived males had higher levels of triglycerides and insulin, and increased body fat composition. Through transcriptomics and proteomics of adult liver, we identified sexually-dimorphic dysregulation of the sterol regulatory element binding protein (SREBP) pathways that are associated with the sex-specific phenotypes. We also found that global loss of DNA methylation in placenta was linked to higher cholesterol levels in IVF-conceived females. Our findings indicate that IVF procedures have long-lasting sex-specific effects on metabolic health of offspring and lay the foundation to utilize the placenta as a predictor of long-term outcomes.
HostingRepository	MassIVE
AnnounceDate	2021-03-16
AnnouncementXML	Submission_2021-03-16_14:47:43.429.xml
DigitalObjectIdentifier
ReviewLevel	Non peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Josue Baeza
SpeciesList	scientific name: Mus musculus; common name: house mouse; NCBI TaxID: 10090;
ModificationList	Carbamidomethyl
Instrument	instrument model

Dataset History

Revision	Datetime	Status	ChangeLog Entry
0	2020-09-18 14:29:54	ID requested
⏵ 1	2021-03-16 14:47:43	announced

Publication List

no publication

no publication

Keyword List

submitter keyword: DIA, Assisted Reproductive Technologies, developmental origins of health and disease (DOHaD)

submitter keyword: DIA, Assisted Reproductive Technologies, developmental origins of health and disease (DOHaD)

Contact List

Bartolomei, Marisa
contact affiliation	University of Pennsylvania
contact email	bartolom@pennmedicine.upenn.edu
lab head
Josue Baeza
contact affiliation	University of Pennsylvania
contact email	baeza@pennmedicine.upenn.edu
dataset submitter

Full Dataset Link List

MassIVE dataset URI
Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://massive.ucsd.edu/MSV000086177/

MassIVE dataset URI

Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://massive.ucsd.edu/MSV000086177/