PXD021554-1

PXD021554 is an original dataset announced via ProteomeXchange.

Title	The Impacts of Surgery and Intracerebral Electrodes in C57BL/6J Mouse Kainate Model of Epileptogenesis: Seizure Threshold, Proteomics, and Cytokine Profiles
Description	ntracranial electroencephalography (EEG) is commonly used to study epileptogenesis and epilepsy in experimental models. Chronic gliosis and neurodegeneration at the injury site are known to be associated with surgically implanted electrodes in both humans and experimental models. Currently, however, there are no reports on the impact of intracerebral electrodes on proteins in the hippocampus and proinflammatory cytokines in the cerebral cortex and plasma in experimental models. We used an unbiased, label-free proteomics approach to identify the altered proteins in the hippocampus, and multiplex assay for cytokines in the cerebral cortex and plasma of C57BL/6J mice following bilateral surgical implantation of electrodes into the cerebral hemispheres.
HostingRepository	PRIDE
AnnounceDate	2021-09-09
AnnouncementXML	Submission_2021-09-09_08:18:09.984.xml
DigitalObjectIdentifier	https://dx.doi.org/10.6019/PXD021554
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Supported dataset by repository
PrimarySubmitter	Maryam Sayadi
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	No PTMs are included in the dataset
Instrument	Thermo Fisher Scientific instrument model; Q Exactive

Revision	Datetime	Status	ChangeLog Entry
0	2020-09-18 01:36:29	ID requested
⏵ 1	2021-09-09 08:18:10	announced
2	2024-02-12 09:03:44	announced	2024-02-12: Updated project metadata.

Tse K, Beamer E, Simpson D, Beynon RJ, Sills GJ, Thippeswamy T, The Impacts of Surgery and Intracerebral Electrodes in C57BL/6J Mouse Kainate Model of Epileptogenesis: Seizure Threshold, Proteomics, and Cytokine Profiles. Front Neurol, 12():625017(2021) [pubmed]

submitter keyword: Intracerebral electrodes, traumatic brain injury, neuroinflammation, proinflammatory cytokines, epilepsy, blood-brain barrier, seizure threshold.

Thimmasettapp Thippeswamy
contact affiliation	Biomedical Sciences , Iowa State University
contact email	tswamy@iastate.edu
lab head
Maryam Sayadi
contact affiliation	Iowa State University
contact email	msayadi@iastate.edu
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2021/09/PXD021554

PRIDE project URI

• PRIDE
  1. PXD021554
     1. Label: PRIDE project
     2. Name: The Impacts of Surgery and Intracerebral Electrodes in C57BL/6J Mouse Kainate Model of Epileptogenesis: Seizure Threshold, Proteomics, and Cytokine Profiles