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PXD021473-1

PXD021473 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleActivity-Dependent Mitochondrial Plasticity and Mitoproteome are Dysregulated in Fragile X Syndrome
DescriptionWe measure changes in the proteome after 48 hours of activity deprivation with tetrodotoxin (TTX) and the NMDA receptor antagonist (2R)-amino-5-phosphonovaleric acid (APV). We used wild type and FMRP mutant primary cortical neurons treated with vehicle or treated with TTX-APV.
HostingRepositoryPRIDE
AnnounceDate2022-02-16
AnnouncementXMLSubmission_2022-02-16_08:02:33.611.xml
DigitalObjectIdentifierhttps://dx.doi.org/10.6019/PXD021473
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportSupported dataset by repository
PrimarySubmitterVictor Faundez
SpeciesList scientific name: Mus musculus (Mouse); NCBI TaxID: 10090;
ModificationListmonohydroxylated residue; iodoacetamide derivatized residue
InstrumentOrbitrap Fusion Lumos
Dataset History
RevisionDatetimeStatusChangeLog Entry
02020-09-14 08:12:28ID requested
12022-02-16 08:02:34announced
Publication List
B, ΓΌ, low P, Zlatic SA, Wenner PA, Bassell GJ, Faundez V, FMRP attenuates activity dependent modifications in the mitochondrial proteome. Mol Brain, 14(1):75(2021) [pubmed]
Keyword List
submitter keyword: Autism, FMR1, Fmrp, Mitochondria, homeostatic plasticity, mitoproteome, Fragile X syndrome
Contact List
Victor Faundez
contact affiliationProfessor, Dept. Cell Biology, Emory University
contact emailvfaunde@emory.edu
lab head
Victor Faundez
contact affiliationEmory University
contact emailvfaunde@emory.edu
dataset submitter
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Dataset FTP location
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