PXD021431-1

PXD021431 is an original dataset announced via ProteomeXchange.

Title	Profiling extra cellular matrix core proteome of human fetal nucleus pulposus in search for regenerative targets
Description	Intervertebral disc degeneration is accompanied by a loss of Extra-cellular matrix (ECM) content due to an imbalance in anabolic and catabolic pathways. Identifying ECM proteins with anabolic and/or regenerative potential could be the key to developing regenerative therapies. Since human fetal discs grow and develop very rapidly, studying these discs may provide valuable insights on proteins with regenerative potential. This study compares core matrisome of 9 fetal and 7 healthy adult (age 22-79) nucleus pulposus (NP), using a proteomic and bioinformatic approach. In order to assess whether the protein that decrease from fetus to healthy adult NP’s further decrease in severely degenerated discs, expression levels of all proteins of interest that were identified in regenerative pathways were used for an additional analysis
HostingRepository	PRIDE
AnnounceDate	2025-01-08
AnnouncementXML	Submission_2025-01-07_18:45:31.774.xml
DigitalObjectIdentifier	https://dx.doi.org/10.6019/PXD021431
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Supported dataset by repository
PrimarySubmitter	Chitraa Tangavel
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	S-carboxamidoethyl-L-cysteine; monohydroxylated residue; iodoacetamide derivatized residue
Instrument	LTQ Orbitrap Velos

Revision	Datetime	Status	ChangeLog Entry
0	2020-09-11 03:00:50	ID requested
⏵ 1	2025-01-07 18:45:32	announced

10.1038/S41598-020-72859-X;

10.6019/PXD021431;

submitter keyword: NP,ESI-LC-MS/MS, Adult, Human, Fetus, Regenerative potential., IVD, Degenerated discs

Dr Chitraa Tangavel
contact affiliation	Research Scientist, Ganga Orthopedic Research and Education Foundation, 187, Mettupalayam Road, Kavundampalayam, Coimbatore- 641030, Tamil Nadu, India
contact email	cthangavel@gmail.com
lab head
Chitraa Tangavel
contact affiliation	Research Scientist, Ganga Orthopedic Research and Education Foundation, 187, Mettupalayam Road, Kavundampalayam, Coimbatore- 641030, Tamil Nadu, India
contact email	cthangavel@gmail.com
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/01/PXD021431

PRIDE project URI

• PRIDE
  1. PXD021431
     1. Label: PRIDE project
     2. Name: Profiling extra cellular matrix core proteome of human fetal nucleus pulposus in search for regenerative targets