PXD021395-1

PXD021395 is an original dataset announced via ProteomeXchange.

Title	Extracellular vesicle proteome of breast cancer patients with and without cognitive impairment following anthracycline-based chemotherapy
Description	Cognitive impairment due to cancer and its therapy is a major concern among cancer survivors. Extracellular vesicles (EVs) composition altered by cancer and chemotherapy may affect neurological processes such as neuroplasticity, potentially impacting the cognitive abilities of cancer survivors. We investigated the EV proteome of breast cancer patients with and without cognitive impairment following anthracycline-based chemotherapy from longitudinally collected plasma. EVs were cup-shaped and positive for Flotillin-1 and TSG-101. We identified 517 differentially expressed EV proteins between the cognitive impaired and non-impaired groups during and post-chemotherapy. The observed decreased expression of p2X purinoceptor, cofilin-1, ADAM 10, and dynamin-1 in the plasma EVs of cognitive impaired group may suggest alterations in mechanisms underlying synaptic plasticity. The reduced expression of tight junction proteins among cognitive-impaired patients may imply weakening of the blood-brain barrier. These EV protein signatures may serve as a fingerprint that underscore the mechanisms underlying cognitive impairment in cancer survivors.
HostingRepository	PRIDE
AnnounceDate	2021-05-27
AnnouncementXML	Submission_2021-05-26_23:02:27.079.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Alexandre Chan
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	amidated residue
Instrument	Dionex instrument model

Revision	Datetime	Status	ChangeLog Entry
0	2020-09-10 01:38:24	ID requested
⏵ 1	2021-05-26 23:02:27	announced

Dataset with its publication pending

ProteomeXchange project tag: Cancer (B/D-HPP), Biology/Disease-Driven Human Proteome Project (B/D-HPP), Human Proteome Project

submitter keyword: extracellular vesicles, cancer, chemotherapy, cognitive impairment, mass spectrometry

Alexandre Chan
contact affiliation	Department of Clinical Pharmacy Practice, University of California, Irvine 92697, USA
contact email	a.chan@uci.edu
lab head
Alexandre Chan
contact affiliation	Department of Clinical Pharmacy Practice, University of California, Irvine 92697, USA
contact email	a.chan@uci.edu
dataset submitter

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PRIDE project URI

• PRIDE
  1. PXD021395
     1. Label: PRIDE project
     2. Name: Extracellular vesicle proteome of breast cancer patients with and without cognitive impairment following anthracycline-based chemotherapy