PXD021338-1

PXD021338 is an original dataset announced via ProteomeXchange.

Title	Proteome of fluid from human ovarian small antral follicles reveals insights in folliculogenesis and oocyte maturation.
Description	Protein composition of human ovarian follicular fluid (FF) constitutes the microenvironment for oocyte development. Several proteomics studies of FF from pre-ovulatory follicles have revealed insights on oocyte maturation, however, there is a lack of knowledge on changes produced at protein levels in the FF of human small antral follicles (hSAF) related to the upcoming oocyte maturation. Using mass spectrometry-based proteomics, we evaluated the protein composition of FF that surrounds oocytes capable to reach metaphase II (MII) after IVM with the protein profile of FF that surrounds immature oocytes. The samples were collected from small antral follicles (size 6.0 ± 1.5 mm) extracted from six women, from which two or three samples were extracted. The comparison was based on both, a multivariate (sPLS-DA) and univariate analyses (t-test).
HostingRepository	PRIDE
AnnounceDate	2021-09-09
AnnouncementXML	Submission_2021-09-09_09:12:12.355.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Indira Pla Parada
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	monohydroxylated residue; iodoacetamide derivatized residue
Instrument	Q Exactive

Revision	Datetime	Status	ChangeLog Entry
0	2020-09-07 00:53:07	ID requested
⏵ 1	2021-09-09 09:12:13	announced

Pla I, Sanchez A, Pors SE, Pawlowski K, Appelqvist R, Sahlin KB, Poulsen LC, Marko-Varga G, Andersen CY, Malm J, Proteome of fluid from human ovarian small antral follicles reveals insights in folliculogenesis and oocyte maturation. Hum Reprod, 36(3):756-770(2021) [pubmed]

submitter keyword: follicular fluid, small antral follicles, proteomics, oocyte maturation.

Johan Malm
contact affiliation	Clinical Chemistry, Department of Translational Medicine, Lund University, Skane University Hospital Malmö, 205 02 Malmö, Sweden.
contact email	johan.malm@med.lu.se
lab head
Indira Pla Parada
contact affiliation	Lund university
contact email	indira.pla_parada@med.lu.se
dataset submitter

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PRIDE project URI

• PRIDE
  1. PXD021338
     1. Label: PRIDE project
     2. Name: Proteome of fluid from human ovarian small antral follicles reveals insights in folliculogenesis and oocyte maturation.