PXD021181-1

PXD021181 is an original dataset announced via ProteomeXchange.

Title	A Novel Role of Wnt/β Catenin Signaling in Regulating the Nucleolus in Triple Negative Breast CancerA Novel Role of Wnt/β Catenin Signaling in Regulating the Nucleolus in Triple Negative Breast Cancer
Description	Breast cancer is one of the most common types of cancer in women. One key signaling pathway known to regulate tumor growth, metabolic adaptation, and cellular stress response in breast cancer is Wnt signaling. Breast cancer patients, specifically triple negative breast cancer (TNBC), with upregulated Wnt signaling often have a poor clinical prognosis. However, the effects of Wnt/β-catenin signaling on the nucleolus and the resultant impact on cancer development and progression remain unclear. A notable reduction was observed in the number of nucleoli per nucleus in response to Wnt/β-catenin signaling inhibition in multiple TNBC cell lines. Our comparative proteomic analysis revealed several changes in the composition of the nucleolar proteome of TNBC cells upon inhibition of Wnt signaling. Overall, we demonstrate that Wnt/β-catenin signaling will affects nucleolar functionality and thus influences breast cancer progression. Understanding the role of Wnt signaling in the nucleolus and breast cancer is a critical step towards developing novel therapeutic options for the treatment of breast cancer.
HostingRepository	PRIDE
AnnounceDate	2021-03-05
AnnouncementXML	Submission_2021-03-04_22:38:11.328.xml
DigitalObjectIdentifier	https://dx.doi.org/10.6019/PXD021181
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Supported dataset by repository
PrimarySubmitter	Brandon Metge
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	No PTMs are included in the dataset
Instrument	LTQ Orbitrap Velos

Revision	Datetime	Status	ChangeLog Entry
0	2020-08-28 00:08:19	ID requested
⏵ 1	2021-03-04 22:38:11	announced

Dataset with its publication pending

submitter keyword: Wnt signaling, Beta Catenin, Triple negative breast cancer, Nucleolus, Nucleolar Proteome, LAS1L

Rajeev Samant
contact affiliation	University of Alabama at Birmingham, Department of Pathology, Division MCP, O'Neal Comprehensive Cancer Center
contact email	rajeevsamant@uabmc.edu
lab head
Brandon Metge
contact affiliation	University of Alabama at Birmingham
contact email	brandonmetge@uabmc.edu
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2021/03/PXD021181

PRIDE project URI

• PRIDE
  1. PXD021181
     1. Label: PRIDE project
     2. Name: A Novel Role of Wnt/β Catenin Signaling in Regulating the Nucleolus in Triple Negative Breast CancerA Novel Role of Wnt/β Catenin Signaling in Regulating the Nucleolus in Triple Negative Breast Cancer