PXD021178 is an
original dataset announced via ProteomeXchange.
Dataset Summary
Title | Proteome in human hematopoietic stem and progenitor cell subpopulations from polycythemia vera patients and controls |
Description | Polycythemia vera (PV) is a myeloproliferative neoplasm (MPN) characterized by hyper-proliferation of the erythroid, megakaryocytic and granulocytic lineages and the presence of an activating mutation in JAK2. To elucidate mechanisms that regulate PV stem cells, we applied a newly developed data-independent acquisition (DIA) mass spectrometry (MS) technology to purified hematopoietic stem and progenitor cell (HSPC) subpopulations of patients with chronic and progressed PV. Proteomic analyses were supplemented by RNA-sequencing (RNA-seq) and identified targets validated by flow cytometry and functional in vitro assays. |
HostingRepository | PRIDE |
AnnounceDate | 2022-01-19 |
AnnouncementXML | Submission_2022-01-19_09:02:28.797.xml |
DigitalObjectIdentifier | |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | Fabienne Meier-Abt |
SpeciesList | scientific name: Homo sapiens (Human); NCBI TaxID: 9606; |
ModificationList | monohydroxylated residue; iodoacetamide derivatized residue |
Instrument | Orbitrap Fusion Lumos |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
0 | 2020-08-27 23:32:43 | ID requested | |
⏵ 1 | 2022-01-19 09:02:29 | announced | |
Publication List
Dataset with its publication pending |
Keyword List
submitter keyword: Human, hematopoietic stem and progenitor cell subpopulations, polycythemia vera |
Contact List
Fabienne Meier-Abt |
contact affiliation | Department of Medical Oncology and Hematology, University and University Hospital Zurich, Zurich, Switzerland Institute of Molecular Systems Biology, ETH Zurich, Zurich, Switzerland |
contact email | fabienne.meier-abt@usz.ch |
lab head | |
Fabienne Meier-Abt |
contact affiliation | University Hospital Zurich ETHZ |
contact email | fabienne.meier-abt@usz.ch |
dataset submitter | |
Full Dataset Link List
Dataset FTP location
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PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD021178
- Label: PRIDE project
- Name: Proteome in human hematopoietic stem and progenitor cell subpopulations from polycythemia vera patients and controls