PXD020908 is an
original dataset announced via ProteomeXchange.
Dataset Summary
Title | Dynamic proteomic profiling of human periodontal ligament stem cells during osteogenic differentiation |
Description | Human periodontal ligament stem cells (hPDLSCs) are ideal seed cells for periodontal regeneration. To better understand the dynamic protein profiles during hPDLSCs osteogenic differentiation, we conducted a quantitative proteomics to reveal the temporal protein expression pattern during this process. Clustering and functional annotation by Gene Ontology terms identified distinctions among proteins with different dynamic tendencies. Pathway enrichment analysis with the Kyoto Encyclopedia of Genes and Genomes database found that oxidative phosphorylation (OXPHOS) was significantly involved, which further predicted continuous activation by Ingenuity Pathway Analysis software. Redox-sensitive signalling pathways with dynamic activation status showed associations with OXPHOS to various degrees, especially the sirtuin signalling pathway. SOD2, an important component of the sirtuin signalling pathway, is a hub protein of the interaction network and displays a persistent increase during osteogenesis. Our in-depth dynamic proteomic analysis indicated the comprehensive and dynamic regulation mechanism during hPDLSC osteogenesis. |
HostingRepository | PRIDE |
AnnounceDate | 2021-02-11 |
AnnouncementXML | Submission_2021-02-11_01:51:00.xml |
DigitalObjectIdentifier | |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | Jianjia Li |
SpeciesList | scientific name: Homo sapiens (Human); NCBI TaxID: 9606; |
ModificationList | No PTMs are included in the dataset |
Instrument | Q Exactive HF |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
0 | 2020-08-14 02:45:29 | ID requested | |
⏵ 1 | 2021-02-11 01:51:01 | announced | |
Publication List
Li J, Wang Z, Huang X, Wang Z, Chen Z, Wang R, Chen Z, Liu W, Wu B, Fang F, Qiu W, Dynamic proteomic profiling of human periodontal ligament stem cells during osteogenic differentiation. Stem Cell Res Ther, 12(1):98(2021) [pubmed] |
Keyword List
submitter keyword: Human, Periodontal, Dynamic expression, TMT |
Contact List
Wei Qiu |
contact affiliation | Department of Stomatology, Nanfang Hospital, Southern Medical University, Guangzhou, China, 510515 |
contact email | qiuweiandmj@163.com |
lab head | |
Jianjia Li |
contact affiliation | Department of Stomatology, Nanfang Hospital, Southern Medical University |
contact email | kathyli199304@outlook.com |
dataset submitter | |
Full Dataset Link List
Dataset FTP location
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PRIDE project URI |
Repository Record List
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[ - ]
- PRIDE
- PXD020908
- Label: PRIDE project
- Name: Dynamic proteomic profiling of human periodontal ligament stem cells during osteogenic differentiation