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PXD020862 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitlePfDOZI protein-protein interaction in plasmodium falciparum
DescriptionHere, we characterized an RNA binding protein (RBP), PfDOZI, which is an integral cytoplasmic component of RNP granule. We observed that deleting pfdozi led to an asexual growth advantage due to the escalated merozoite invasion capacity. Also, pfdozi disruption resulted in a significant impairment in gametocyte commitment and morphology development. Through high-throughput RNA-seq, we revealed that PfDOZI affected the transcriptome in both asexual and sexual stages when pfdozi was deleted. Mechanically, we confirmed that PfDOZI could interact with P body like mRNP in the schizont stage, while stress granule-like granule in gametocyte stage. The identification of PfDOZI protein complex in stressed schizont further indicate PfDOZI could shift its function from mRNA degradation to translation repression during stage conversion.
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportSupported dataset by repository
PrimarySubmitterHUI MIN
SpeciesList scientific name: Plasmodium falciparum; NCBI TaxID: 5833;
ModificationListNo PTMs are included in the dataset
Dataset History
RevisionDatetimeStatusChangeLog Entry
02020-08-12 01:26:31ID requested
12024-04-15 19:12:16announced
Publication List
Keyword List
submitter keyword: PfDOZI, asexual stage, sexual stage, Plasmodium falciparum, LC-MS/MS
Contact List
Liwang Cui
contact affiliationDivision of Infectious Diseases and International Medicine Department of Internal Medicine Morsani College of Medicine University of South Florida
contact emailliwangcui@usf.edu
lab head
contact affiliationUniversity of South Florida
contact emailhuim868@gmail.com
dataset submitter
Full Dataset Link List
Dataset FTP location
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PRIDE project URI
Repository Record List
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