PXD020743-2

PXD020743 is an original dataset announced via ProteomeXchange.

Title	Tubulin Tyrosine Ligase Like 4 (TTLL4) overexpression in breast cancer cells alters exosome biogenesis and promotes brain metastasis
Description	The survival rate is poor in breast cancer patients with brain metastases. Thus, new concepts for therapeutic approaches are required. During metastasis, the cytoskeleton of cancer cells is highly dynamic and therefore cytoskeleton-associated proteins are interesting targets for tumour therapy.
HostingRepository	PRIDE
AnnounceDate	2021-08-20
AnnouncementXML	Submission_2021-08-20_03:01:06.880.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Christoph Krisp
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	iodoacetamide derivatized residue
Instrument	Q Exactive

Revision	Datetime	Status	ChangeLog Entry
0	2020-08-05 09:41:01	ID requested
1	2021-08-20 00:25:37	announced
⏵ 2	2021-08-20 03:01:07	announced	2021-08-20: Updated project metadata.

Arnold J, Schattschneider J, Blechner C, Krisp C, Schl, ü, ter H, Schweizer M, Nalaskowski M, Oliveira-Ferrer L, Windhorst S, Tubulin Tyrosine Ligase Like 4 (TTLL4) overexpression in breast cancer cells is associated with brain metastasis and alters exosome biogenesis. J Exp Clin Cancer Res, 39(1):205(2020) [pubmed]

10.1186/S13046-020-01712-W;

submitter keyword: exosome, microtubule, polyglutamylation,breast cancer, metastasis

Sabine Windhorst
contact affiliation	Department of Biochemistry and Signal Transduction, University Medical Center Hamburg-Eppendorf, Hamburg, Germany
contact email	s.windhorst@uke.de
lab head
Christoph Krisp
contact affiliation	University Medical Center Hamburg-Eppendorf Institute of Clinical Chemistry and Laboratory Medicine Mass Spectrometric Proteomics
contact email	c.krisp@uke.de
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2021/08/PXD020743

PRIDE project URI

• PRIDE
  1. PXD020743
     1. Label: PRIDE project
     2. Name: Tubulin Tyrosine Ligase Like 4 (TTLL4) overexpression in breast cancer cells alters exosome biogenesis and promotes brain metastasis