PXD020663 is an
original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Mechano-regulated RNA binding protein hnRNPC contributes to RNA homeostasis in heart failure |
| Description | Cardiac pathologies are characterized by intense remodeling of the extracellular matrix (ECM) that eventually leads to heart failure. Cardiomyocytes respond to the ensuing biomechanical stress by re-expressing fetal contractile proteins via transcriptional and post-transcriptional processes, like alternative splicing (AS). Here, we demonstrate that the heterogeneous nuclear ribonucleoprotein C (hnRNPC) is upregulated and relocates to the sarcomeric Z-disk upon ECM pathological remodeling. At this site, the protein participates to the localized translation of mRNAs encoding sarcomeric proteins. Alterations in hnRNPC expression and localization can be mechanically determined and affect the AS of numerous mRNAs involved in mechanotransduction and cardiovascular diseases. We thus propose that cardiac ECM remodeling serves as a switch in RNA metabolism by directly impacting an associated regulatory protein of the spliceosome apparatus. These findings offer new insights on the mechanism of mRNAs homeostasis mechanoregulation in disease conditions. |
| HostingRepository | PRIDE |
| AnnounceDate | 2026-07-06 |
| AnnouncementXML | Submission_2026-07-06_04:15:55.237.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Carina Sihlbom |
| SpeciesList | scientific name: Homo sapiens (Human); NCBI TaxID: NEWT:9606; |
| ModificationList | TMT6plex-126 reporter+balance reagent acylated residue; iodoacetamide derivatized residue |
| Instrument | Orbitrap Fusion Lumos |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|
| 0 | 2020-07-30 22:29:55 | ID requested | |
| ⏵ 1 | 2026-07-06 04:15:56 | announced | |
Publication List
| Martino F, Varadarajan NM, Perestrelo AR, Hejret V, Durikova H, Vukic D, Horvath V, Cavalieri F, Caruso F, Albihlal WS, Gerber AP, O'Connell MA, Vanacova S, Pagliari S, Forte G, The mechanical regulation of RNA binding protein hnRNPC in the failing heart. Sci Transl Med, 14(672):eabo5715(2022) [pubmed] |
| 10.1126/scitranslmed.abo5715; |
Keyword List
| submitter keyword: proteomics, TMT, IP,hnRNPC, heart failure, RNA homeostasis |
Contact List
| Carina Sihlbom |
|---|
| contact affiliation | Proteomics Core Facility, University of Gothenburg |
| contact email | carina.sihlbom@gu.se |
| lab head | |
| Carina Sihlbom |
|---|
| contact affiliation | Proteomics Core Facility / University of Gothenburg |
| contact email | carina.sihlbom@gu.se |
| dataset submitter | |
Full Dataset Link List
Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/07/PXD020663 |
| PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD020663
- Label: PRIDE project
- Name: Mechano-regulated RNA binding protein hnRNPC contributes to RNA homeostasis in heart failure
