PXD020539-1

PXD020539 is an original dataset announced via ProteomeXchange.

Dataset Summary

Title	Contribution of the Unfolded Protein Response (UPR) transcription factor XBP1 to brain aging
Description	In this project we aimed to evaluate the contribution of endoplasmic reticulum stress sensor IRE1 and its downstream transcription factor XBP1s to mammalian brain aging. We compared traits associated to aging at behavioral, electrophysiological, morphological and proteomic levels. We used transgenic animals overexpressing XBP1s in brain tissue and also wild type animals injected with adeno-associated virus to overexpress XBP1s in the brain during aging.
HostingRepository	PRIDE
AnnounceDate	2022-11-04
AnnouncementXML	Submission_2022-11-04_05:19:58.095.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	LarsPlate
SpeciesList	scientific name: Mus musculus (Mouse); NCBI TaxID: 10090;
ModificationList	TMT6plex-126 reporter+balance reagent acylated residue; iodoacetamide derivatized residue
Instrument	Q Exactive HF

Dataset History

Revision	Datetime	Status	ChangeLog Entry
0	2020-07-23 17:45:48	ID requested
⏵ 1	2022-11-04 05:19:58	announced
2	2023-11-14 08:51:22	announced	2023-11-14: Updated project metadata.

Publication List

Keyword List

submitter keyword: unfolded protein response, XBP1s, dementia, aging

submitter keyword: unfolded protein response, XBP1s, dementia, aging

Contact List

LarsPlate
contact affiliation	Vanderbilt University
contact email	lars.plate@vanderbilt.edu
lab head
LarsPlate
contact affiliation	Vanderbilt University
contact email	lars.plate@vanderbilt.edu
dataset submitter

Full Dataset Link List

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PRIDE project URI

Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2022/11/PXD020539

PRIDE project URI

Repository Record List

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