PXD020271 is an
original dataset announced via ProteomeXchange.
Dataset Summary
| Title | BRCA1-dependent ubiquitination and phosphorylation regulates signaling events in high-grade serous ovarian cancer tissues |
| Description | Despite recent advances in the management of BRCA1 mutated high-grade serous ovarian cancer (HGSC), the physiology of these tumors remains poorly understood. Here we provide a comprehensive molecular understanding of the signaling processes that drive HGSC pathogenesis and their dependency on BRCA1 mutation-state directly in patient-derived tissues. Using a multi-layered proteomic approach, we show the tight coordination between the ubiquitination and phosphorylation regulatory layers and their role in key cellular processes related to BRCA1-dependent HGSC pathogenesis. In addition, we identify key bridging proteins, kinase activity, and post-translational modifications responsible for molding distinct cancer phenotypes, thus providing new opportunities for therapeutic intervention, and ultimately advance towards a more personalized patient care. |
| HostingRepository | PRIDE |
| AnnounceDate | 2022-05-25 |
| AnnouncementXML | Submission_2022-05-25_03:12:45.380.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Melissa Bradbury |
| SpeciesList | scientific name: Homo sapiens (Human); NCBI TaxID: 9606; |
| ModificationList | ubiquitination signature dipeptidyl lysine; phosphorylated residue |
| Instrument | Orbitrap Fusion Lumos |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|
| 0 | 2020-07-09 02:21:10 | ID requested | |
| ⏵ 1 | 2022-05-25 03:12:46 | announced | |
| 2 | 2023-05-14 14:21:42 | announced | 2023-05-14: Updated project metadata. |
| 3 | 2024-10-22 05:36:50 | announced | 2024-10-22: Updated project metadata. |
Publication List
| Bradbury M, Borr, à, s E, Castellv, í J, M, é, ndez O, S, á, nchez-Iglesias JL, P, é, rez-Benavente A, Gil-Moreno A, Sabid, ó E, Santamaria A, BRCA1 mutations in high-grade serous ovarian cancer are associated with proteomic changes in DNA repair, splicing, transcription regulation and signaling. Sci Rep, 12(1):4445(2022) [pubmed] |
Keyword List
| submitter keyword: BRCA1, ovarian cancer, proteomics, ubiquitination, phosphorylation |
Contact List
| Eduard Sabidó |
|---|
| contact affiliation | Proteomics Unit, Centre de Regulació Genòmica, Barcelona Institute of Science and Technology (BIST), Dr Aiguader 88, 08003 Barcelona, Spain. Universitat Pompeu Fabra, Dr Aiguader 88, 08003 Barcelona, Spain. |
| contact email | eduard.sabido@crg.eu |
| lab head | |
| Melissa Bradbury |
|---|
| contact affiliation | Vall d'Hebron Barcelona Hospital Campus |
| contact email | mbradbury@vhebron.net |
| dataset submitter | |
Full Dataset Link List
Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2022/04/PXD020271 |
| PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD020271
- Label: PRIDE project
- Name: BRCA1-dependent ubiquitination and phosphorylation regulates signaling events in high-grade serous ovarian cancer tissues
to receive all new ProteomeXchange dataset release announcements!
