PXD020211-1

PXD020211 is an original dataset announced via ProteomeXchange.

Title	Saliva peptidome correlates with oral cancer prognosis
Description	Protease activity has been associated with pathological processes that can lead to cancer development and progression. However, understanding the pathological unbalance in proteolysis is challenging since changes can occur simultaneously at protease, their inhibitor and substrate levels. In this work we combined peptidomics, proteomics and peptidase predictions for studying proteolytic events in saliva associated with oral squamous cell carcinoma (OSCC) prognosis. Our results suggest that cleavage products differentially abundant in the saliva of patients with (N+) or without (N0) nodal metastasis exhibit potential of prognostic value in oral cancer and were are able to discriminate N+ and N0 patients whereas reduced protein levels of peptidase inhibitors might disturb the proteolytic balance in saliva of OSCC patients with poor prognosis
HostingRepository	PRIDE
AnnounceDate	2020-11-13
AnnouncementXML	Submission_2020-11-13_07:59:44.xml
DigitalObjectIdentifier	https://dx.doi.org/10.6019/PXD020211
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Supported dataset by repository
PrimarySubmitter	Leandro Neves
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	No PTMs are included in the dataset
Instrument	LTQ Orbitrap Velos

Revision	Datetime	Status	ChangeLog Entry
0	2020-07-06 00:57:01	ID requested
⏵ 1	2020-11-13 07:59:45	announced
2	2024-10-22 05:15:02	announced	2024-10-22: Updated project metadata.

Dataset with its publication pending

submitter keyword: oral cancer, peptidome, proteolysis, protease inhibitors, oral squamous cell carcinoma

Adriana Franco Paes Leme
contact affiliation	National Laboratory of Biosciences, CNPEM, Campinas,Brazil
contact email	adriana.paesleme@lnbio.cnpem.br
lab head
Leandro Neves
contact affiliation	Postdoctoral research assistant at Brazilian National Biosciences Laboratory (LNBio), CNPEM, Campinas, Brazil
contact email	leandroxneves@gmail.com
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2020/11/PXD020211

PRIDE project URI

• PRIDE
  1. PXD020211
     1. Label: PRIDE project
     2. Name: Saliva peptidome correlates with oral cancer prognosis