PXD020085-1

PXD020085 is an original dataset announced via ProteomeXchange.

Title	Proteomic analysis of successful and biologically compromised bone fracture healing
Description	Bone fracture healing shows approximately 10-15% non-unions, although theoretically it has the potential of scarless regeneration. With regards to our aging society, a better understanding of the healing process is needed to allow for more sophisticated treatment options. Particular the early phase, which is a high complex and dynamic process in regards to nutrient and engery requirements. Here we investigate the proteomic (and metabolic) characteristics of the local microenvironment from successful (in young female Sprague-Dawley rats) and biologically compromised (in aged female rats with a minimum litter of three)bone reneration at day 3, 7 and 14 after osteotomy.
HostingRepository	PRIDE
AnnounceDate	2023-05-10
AnnouncementXML	Submission_2023-05-10_10:03:58.418.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	JuliaLöffler
SpeciesList	scientific name: Rattus norvegicus (Rat); NCBI TaxID: 10116;
ModificationList	monohydroxylated residue; acetylated residue; iodoacetamide derivatized residue
Instrument	LTQ Orbitrap Velos

Revision	Datetime	Status	ChangeLog Entry
0	2020-06-29 02:18:21	ID requested
⏵ 1	2023-05-10 10:03:59	announced
2	2023-11-14 08:46:15	announced	2023-11-14: Updated project metadata.

L, ö, ffler J, Noom A, Ellinghaus A, Dienelt A, Kempa S, Duda GN, A comprehensive molecular profiling approach reveals metabolic alterations that steer bone tissue regeneration. Commun Biol, 6(1):327(2023) [pubmed]

submitter keyword: LC-MS, Bone,Rattus norvegius

StefanKempa
contact affiliation	Berlin Institute for Medical Systems Biology, Max-Delbrück-Center for Molecular Medicine, 10115, Berlin, Germany
contact email	stefan.kempa@mdc-buch.de
lab head
JuliaLöffler
contact affiliation	B(IH)CRT, Charité Universitätsmedizin Berlin, Germany Julius Wolff Institut, Charité Universitätsmedizin Berlin, Germany BIMBS, MDC-Berlin Buch, Germany
contact email	julia.loeffler@charite.de
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2023/05/PXD020085

PRIDE project URI

• PRIDE
  1. PXD020085
     1. Label: PRIDE project
     2. Name: Proteomic analysis of successful and biologically compromised bone fracture healing