PXD020024-1

PXD020024 is an original dataset announced via ProteomeXchange.

Title	Fallopian tube lesions as potential precursors of early ovarian cancer: A comprehensive proteomic analysis.
Description	The main goal of this study is to explore the proteomic expression in prophylactic salpingooophorectomy specimens, obtained from highly selected cohort of patients at risk of developing a high-grade serous ovarian carcinoma (HGSOC), because of a hereditary (BRCA 1 or 2 mutation) or a documented familial context. Pathological aspects of fallopian tube specimens, at the origin of most HGSOC in this selected feminine population, are extracted from slides annotated by the pathologist, then submitted to a proteomic analysis. We carried out an in-depth proteomics analysis of these epithelial lesions (p53 signature, serous tubal intraepithelial carcinoma-STIC and serous tubal intraepithelial lesions-STIL) based on spatially resolved proteomic guided by IHC technique.
HostingRepository	PRIDE
AnnounceDate	2023-10-24
AnnouncementXML	Submission_2023-10-24_10:36:21.912.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	MaxenceWisztorski
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	monohydroxylated residue; acetylated residue
Instrument	Q Exactive

Revision	Datetime	Status	ChangeLog Entry
0	2020-06-25 18:28:36	ID requested
⏵ 1	2023-10-24 10:36:22	announced
2	2023-11-14 09:06:37	announced	2023-11-14: Updated project metadata.
3	2024-10-22 06:08:04	announced	2024-10-22: Updated project metadata.

Wisztorski M, Aboulouard S, Roussel L, Duhamel M, Saudemont P, Cardon T, Narducci F, Robin YM, Lemaire AS, Bertin D, Hajjaji N, Kobeissy F, Leblanc E, Fournier I, Salzet M, Fallopian tube lesions as potential precursors of early ovarian cancer: a comprehensive proteomic analysis. Cell Death Dis, 14(9):644(2023) [pubmed]

submitter keyword: pre-neoplastic lesions,Oavrian cancer, spatially resolved proteomics, IHC, Proteomics

MichelSalzet
contact affiliation	Univ.Lille, Inserm, CHU Lille, U1192 - Protéomique Réponse Inflammatoire Spectrométrie de Masse - PRISM, F-59000 Lille, France
contact email	michel.salzet@univ-lille.fr
lab head
MaxenceWisztorski
contact affiliation	University of Lille
contact email	maxence.wisztorski@univ-lille1.fr
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2023/10/PXD020024

PRIDE project URI

• PRIDE
  1. PXD020024
     1. Label: PRIDE project
     2. Name: Fallopian tube lesions as potential precursors of early ovarian cancer: A comprehensive proteomic analysis.