PXD019826-2

PXD019826 is an original dataset announced via ProteomeXchange.

Title	The mitochondrial transporter SFXN1 is critical for Complex III integrity and cellular metabolism
Description	Mutations in acylglycerol kinase (AGK) leads to Sengers syndrome, a rare disease characterized by skeletal myopathy, hypertrophic cardiomyopathy, and cataracts. AGK, in vitro, produces lysophosphatidic acid and phosphatidic acid via phosphorylation of monoacylglycerol and diacylglycerol, accordingly. AGK is also a component of the TIM22 import machinery in the inner mitochondrial membrane and, independent of its kinase activity, has been shown to mediate the import of mitochondrial carrier family (SLC25) members. We compared the proteomes of mitochondria from HEK293 WT and AGK KO cells in order to identify additional candidate substrates of the TIM22 translocase that relies on AGK.
HostingRepository	PRIDE
AnnounceDate	2024-10-22
AnnouncementXML	Submission_2024-10-22_05:07:25.053.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Akhilesh Pandey
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	iodoacetamide derivatized residue
Instrument	Orbitrap Fusion Lumos

Revision	Datetime	Status	ChangeLog Entry
0	2020-06-16 23:31:41	ID requested
1	2020-06-17 22:24:29	announced
⏵ 2	2024-10-22 05:07:25	announced	2024-10-22: Updated project metadata.

Dataset with its publication pending

submitter keyword: Mitochondria,AGK

Steven Claypool
contact affiliation	Department of Physiology, Johns Hopkins University School of Medicine, 725 N Wolfe St, Baltimore, Maryland, USA 21205
contact email	sclaypo1@jhmi.edu
lab head
Akhilesh Pandey
contact affiliation	Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN 55905
contact email	pandey.akhilesh@mayo.edu
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2020/06/PXD019826

PRIDE project URI

• PRIDE
  1. PXD019826
     1. Label: PRIDE project
     2. Name: The mitochondrial transporter SFXN1 is critical for Complex III integrity and cellular metabolism