PXD019679-2

PXD019679 is an original dataset announced via ProteomeXchange.

Title	GHB analogs confer neuroprotection through specific interaction with the CaMKII hub domain
Description	Ca2+/calmodulin-dependent protein kinase II alpha (CaMK2A) is an emerging drug target incerebral ischemia for which limited therapeutic options exist. Here we show that small-molecule analogs of the brain metabolite gamma-hydroxybutyric acid (GHB) afford neuroprotection via interaction specifically with the CaMK2A hub domain. Identification of CaMK2A as the GHB analog target was achieved by homogenate photoaffinity labeling followed by quantitative proteomics
HostingRepository	PRIDE
AnnounceDate	2024-10-22
AnnouncementXML	Submission_2024-10-22_05:24:13.479.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Ulrike Leurs
SpeciesList	scientific name: Rattus norvegicus (Rat); NCBI TaxID: 10116;
ModificationList	biotinylated residue
Instrument	Q Exactive HF

Revision	Datetime	Status	ChangeLog Entry
0	2020-06-09 13:05:25	ID requested
1	2021-07-22 03:48:54	announced
⏵ 2	2024-10-22 05:24:13	announced	2024-10-22: Updated project metadata.

Dataset with its publication pending

submitter keyword: QExactive HF, brain homogenate, affinity purification, photoaffinity labeling, rat

Jesper V. Olsen
contact affiliation	Novo Nordisk Foundation Center for Protein Research, University of Copenhagen (Denmark)
contact email	jesper.olsen@cpr.ku.dk
lab head
Ulrike Leurs
contact affiliation	University of Copenhagen, Denmark
contact email	ulrike.leurs@gmail.com
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2021/07/PXD019679

PRIDE project URI

• PRIDE
  1. PXD019679
     1. Label: PRIDE project
     2. Name: GHB analogs confer neuroprotection through specific interaction with the CaMKII hub domain