PXD019675-1

PXD019675 is an original dataset announced via ProteomeXchange.

Title	Gut microbiota may underlie the predisposition of healthy individuals to COVID-19
Description	The COVID-19 pandemic is spreading globally with high disparity in the susceptibility of the disease severity. Identification of the key underlying factors for this disparity is highly warranted. Here we describe constructing a proteomic risk score based on 20 blood proteomic biomarkers which predict the progression to severe COVID-19. We demonstrate that in our own cohort without infection, this proteomic risk score is positively associated with proinflammatory cytokines mainly among older, but not younger, individuals. We further discovered that a core set of gut microbiota could accurately predict the above proteomic biomarkers using a machine learning model, and that these gut microbiota features are highly correlated with proinflammatory cytokines.
HostingRepository	iProX
AnnounceDate	2020-06-09
AnnouncementXML	Submission_2022-03-06_19:52:28.574.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Ju-sheng Zheng
SpeciesList	scientific name: Homo sapiens; NCBI TaxID: 9606;
ModificationList	No PTMs are included in the dataset
Instrument	TripleTOF 5600

Revision	Datetime	Status	ChangeLog Entry
0	2020-06-09 08:50:21	ID requested
⏵ 1	2022-03-06 19:52:29	announced
2	2022-03-06 21:33:49	announced	2022-03-07: Update publication information.
3	2022-03-06 21:38:23	announced	2022-03-07: Update publication information. 2022-03-07: Update information.

Dataset with its publication pending

submitter keyword: Proteomics, gut microbiota

Ju-sheng Zheng
contact affiliation	Westlake University
contact email	zhengjusheng@westlake.edu.cn
lab head
Ju-sheng Zheng
contact affiliation	Westlake University
contact email	zhengjusheng@westlake.edu.cn
dataset submitter

iProX dataset URI