PXD019638 is an
original dataset announced via ProteomeXchange.
Dataset Summary
Title | GPX4-dependent Glutathione (GSH) high consumption drives platinum chemotherapeutic resistance by inhibiting ferroptosis in lung cancer derived brain metastasis |
Description | Platinum-based chemotherapy is effective in inducing shrinkage of primary lung cancer lesions; however, it shows limited therapeutic efficacy in patients with brain metastasis (BM). In this study, we utilized a BM model of PC9 lung adenocarcinoma cells and found that the derivative brain metastatic subpopulations (PC9-BrMs) of parental cells PC9 developed obvious resistance to platinum; this suggested that the acquisition of chemo-resistance by brain metastatic cells is attributable to the intrinsic changes in the metastatic cells. Therefore, we performed an integrated profiling of metabolomics and proteomics, and described a radically altered spectrum of BM metabolism and protein expression compared with primary lung cancer cells. We identified a unique metabolite status characterized by high consumption of glutathione (GSH) for antioxidant stress response, both in BM cells and clinical serum samples. |
HostingRepository | PRIDE |
AnnounceDate | 2022-02-15 |
AnnouncementXML | Submission_2022-02-15_13:08:56.501.xml |
DigitalObjectIdentifier | |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | Qi Wang |
SpeciesList | scientific name: Homo sapiens (Human); NCBI TaxID: 9606; |
ModificationList | No PTMs are included in the dataset |
Instrument | quadrupole |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
0 | 2020-06-07 23:30:02 | ID requested | |
⏵ 1 | 2022-02-15 13:08:57 | announced | |
Publication List
Liu W, Zhou Y, Duan W, Song J, Wei S, Xia S, Wang Y, Du X, Li E, Ren C, Wang W, Zhan Q, Wang Q, Glutathione peroxidase 4-dependent glutathione high-consumption drives acquired platinum chemoresistance in lung cancer-derived brain metastasis. Clin Transl Med, 11(9):e517(2021) [pubmed] |
Keyword List
submitter keyword: lung cancer |
brain metastasis |
chemotherapeutic resistance |
ferroptosis |
glutathione metabolism |
GPX4 |
Contact List
Qi Wang |
contact affiliation | The Second Hospital of Dalian Medical University |
contact email | wqdlmu@163.com |
lab head | |
Qi Wang |
contact affiliation | The Second Hospital of Dalian Medical University |
contact email | wqdlmu@163.com |
dataset submitter | |
Full Dataset Link List
Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2022/02/PXD019638 |
PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD019638
- Label: PRIDE project
- Name: GPX4-dependent Glutathione (GSH) high consumption drives platinum chemotherapeutic resistance by inhibiting ferroptosis in lung cancer derived brain metastasis