PXD019528-2

PXD019528 is an original dataset announced via ProteomeXchange.

Title	Cigarette smoke extract-treated alveolar macrophage-derived extracellular vesicles
Description	This project is based upon the fundamental observation that alveolar macrophage-derived extracellular vesicles (AM-EVs), when internalized by neighboring epithelial cells, inhibit their infection by influenza virus. This inhibitory activity of AM-EVs is abolished when AMs are treated with cigarette smoke extract (CSE). We chose to survey the AM-EV proteome in an effort to identify candidate proteins whose abundance within EVs was downregulated by CSE treatment of AMs, thus explaining the ability of CSE to abrogate the inhibitory activity against influenza.
HostingRepository	PRIDE
AnnounceDate	2024-10-22
AnnouncementXML	Submission_2024-10-22_05:06:53.126.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Daniel Schneider
SpeciesList	scientific name: Mus musculus (Mouse); NCBI TaxID: 10090;
ModificationList	TMT6plex-126 reporter+balance reagent acylated residue
Instrument	Orbitrap Fusion

Revision	Datetime	Status	ChangeLog Entry
0	2020-06-02 18:17:59	ID requested
1	2020-06-08 16:58:25	announced
⏵ 2	2024-10-22 05:06:53	announced	2024-10-22: Updated project metadata.

Dataset with its publication pending

submitter keyword: extracellular vesicle,Alveolar macrophage, cigarette smoke

Daniel Joseph Schneider
contact affiliation	Department of Internal Medicine Division of Pulmonary and Critical Care Medicine, University of Michigan, Ann Arbor, MI, USA
contact email	schneidd@umich.edu
lab head
Daniel Schneider
contact affiliation	University of Michigan
contact email	schneidd@med.umich.edu
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2020/06/PXD019528

PRIDE project URI

• PRIDE
  1. PXD019528
     1. Label: PRIDE project
     2. Name: Cigarette smoke extract-treated alveolar macrophage-derived extracellular vesicles