PXD019484-2

PXD019484 is an original dataset announced via ProteomeXchange.

Title	Mitochondrial protein interaction landscape of SS-31
Description	SS-31 is a synthetic peptide that improves mitochondrial function and is currently undergoing clinical trials for treatments of heart failure, primary mitochondrial myopathy, and other mitochondrial diseases. SS-31 interacts with cardiolipin which is abundant in the inner mitochondrial membrane, but mechanistic details of its pharmacological effects are unknown. Here we apply a chemical cross-linking/mass spectrometry method to provide direct evidence for specific interactions between SS-31 and mitochondrial proteins. The identified SS-31 interactors are functional components in ATP production and 2-oxoglutarate metabolism and signaling, consistent with improved mitochondrial function resultant from SS-31 treatment. These results offer a glimpse of the protein interaction landscape of SS-31 and provide mechanistic insight relevant to SS-31 mitochondrial therapy
HostingRepository	PRIDE
AnnounceDate	2024-10-22
AnnouncementXML	Submission_2024-10-22_05:07:12.680.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Juan Chavez
SpeciesList	scientific name: Mus musculus (Mouse); NCBI TaxID: 10090;
ModificationList	monohydroxylated residue; iodoacetamide derivatized residue
Instrument	LTQ FT; Q Exactive

Revision	Datetime	Status	ChangeLog Entry
0	2020-06-01 03:10:26	ID requested
1	2020-06-11 16:15:03	announced
⏵ 2	2024-10-22 05:07:13	announced	2024-10-22: Updated project metadata.

Dataset with its publication pending

submitter keyword: cross-linking mass spectometry,mitochondria, SS-31, mouse, elamipretide

James E. Bruce
contact affiliation	Department of Genome Sciences, University of Washington
contact email	jimbruce@uw.edu
lab head
Juan Chavez
contact affiliation	University of Washington
contact email	jdchavez@uw.edu
dataset submitter

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PRIDE project URI

• PRIDE
  1. PXD019484
     1. Label: PRIDE project
     2. Name: Mitochondrial protein interaction landscape of SS-31