PXD019477-2

PXD019477 is an original dataset announced via ProteomeXchange.

Title	Ileal proteomic changes associated with IL-25-mediated resistance against intestinal trematode infections
Description	Previous studies of our group have shown that IL-25 is essential for the resistance to E. caproni infections and the susceptibility of mice relies on the inability of this host species to produce IL-25 in response to infection (14-15). Susceptibility of mice to primary E. caproni infection was associated with low levels of intestinal IL-25 expression, whilst deworming via administration of praziquantel (pzq) was accompanied by a steady increase in IL-25 expression and, in turn, by the onset of a Th2-type response that prevented the establishment of secondary infections (14-15). Although these facts, little is known about the mechanism by which IL-25 generates resistance against intestinal helminths. In the present work, we analyze the changes in the production of proteins induced by IL-25 in the ileum of mice that may be involved in the generation of resistance against intestinal helminths.
HostingRepository	PRIDE
AnnounceDate	2024-10-22
AnnouncementXML	Submission_2024-10-22_05:27:30.203.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Luz Valero
SpeciesList	scientific name: Mus musculus (Mouse); NCBI TaxID: 10090;
ModificationList	No PTMs are included in the dataset
Instrument	TripleTOF 5600

Revision	Datetime	Status	ChangeLog Entry
0	2020-05-29 18:12:03	ID requested
1	2021-09-08 19:17:23	announced
⏵ 2	2024-10-22 05:27:38	announced	2024-10-22: Updated project metadata.

Á, lvarez-Izquierdo M, Guillermo Esteban J, Mu, ñ, oz-Antoli C, Toledo R, Ileal proteomic changes associated with IL-25-mediated resistance against intestinal trematode infections. Parasit Vectors, 13(1):336(2020) [pubmed]

10.1186/s13071-020-04206-y;

submitter keyword: intestine,proteomics, intestinal helminths, Echinostoma caproni, trematoda, interleukin-25

Rafael Toledo
contact affiliation	Área de Parasitología, Departamento de Farmacia y Tecnología Farmacéutica y Parasitología, Facultad de Farmacia, Universitat de València, Spain
contact email	rafael.toledo@uv.es
lab head
Luz Valero
contact affiliation	Universitat de Valencia
contact email	mluz.valero@uv.es
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2021/09/PXD019477

PRIDE project URI

• PRIDE
  1. PXD019477
     1. Label: PRIDE project
     2. Name: Ileal proteomic changes associated with IL-25-mediated resistance against intestinal trematode infections