PXD019434-1

PXD019434 is an original dataset announced via ProteomeXchange.

Title	Discovery of biomarker candidates associated with the risk of short- and long-term relapse after infliximab withdrawal in Crohn’s patients: a proteomics-based study
Description	Objective: A subset of Crohn’s disease (CD) patients experiences long-term remission after infliximab withdrawal. Biomarkers are needed to identify those patients. Design: New biomarkers of relapse were searched in the baseline serum of CD patients stopping infliximab when they were under combined therapy (antimetabolite and infliximab) and stable clinical remission (STORI cohort, n=102). From shotgun proteomics experiment (discovery step), biomarker candidates were identified and further targeted by selected reaction monitoring (verification step). The dataset was stratified to search for markers of short- (<6 months) or long-term relapse (>6 months). The risk of relapse and the predicting capacity associated with biomarker candidates were evaluated using univariate Cox model and log-rank statistic, respectively. To test their complementary predicting capacity, biomarker candidates were systematically combined in pairs. Results: Distinct biomarker candidates were associated with the risk (hazard ratio: HR) of short- (15 proteins, 2.9
HostingRepository	PanoramaPublic
AnnounceDate	2020-11-02
AnnouncementXML	Submission_2020-11-02_20:24:54.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Supported dataset by repository
PrimarySubmitter	Nicolas Pierre
SpeciesList	scientific name: Homo sapiens; NCBI TaxID: 9606;
ModificationList	Carbamidomethyl; Label:13C(6)15N(2)
Instrument	Xevo TQ-S

Revision	Datetime	Status	ChangeLog Entry
0	2020-05-27 21:54:54	ID requested
⏵ 1	2020-11-02 20:24:55	announced

Pierre N, Baiwir D, Huynh-Thu VA, Mazzucchelli G, Smargiasso N, De Pauw E, Bouhnik Y, Laharie D, Colombel JF, Meuwis MA, Louis E, Discovery of biomarker candidates associated with the risk of short-term and mid/long-term relapse after infliximab withdrawal in Crohn's patients: a proteomics-based study. Gut, ():(2020) [pubmed]

submitter keyword: Crohn's disease, biomarkers, relapse, selected reaction monitoring

Edouard Louis
contact affiliation	Laboratory of Translational Gastroenterology, GIGA-institute, University of Liège
contact email	edouard.Louis@uliege.be
lab head
Nicolas Pierre
contact affiliation	Laboratory of Translational Gastroenterology, GIGA-institute, University of Liège, Liège, Belgium
contact email	nicolas.pierre@uliege.be
dataset submitter

Panorama Public dataset URI