PXD019380-1

PXD019380 is an original dataset announced via ProteomeXchange.

Title	The Caveolin3 complex stabilizes functional surface expression of the Lactate-Proton Shuttle McT1 but not the sodium channel Nav1.5 in cardiomyocytes
Description	Caveolin3 variants were associated with action potential prolongation. As Caveolin1 was recently identified in cardiomyocytes, we hypothesize that conserved isoform-specific protein interactions underlie human loss-of-function variants. To analyze the Caveolin1 and Caveolin3 interactome, we developed unbiased live-cell proteomic and isoform-specific mass spectrometry techniques. We demonstrate the functional relevance and pathogenic mechanism of a novel Caveolin3 interactor in gene-edited human iPSC-cardiomyocyte models.
HostingRepository	PRIDE
AnnounceDate	2022-10-30
AnnouncementXML	Submission_2022-10-30_11:52:47.689.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	ChristofLenz
SpeciesList	scientific name: Mus musculus (Mouse); NCBI TaxID: 10090;
ModificationList	No PTMs are included in the dataset
Instrument	Q Exactive

Revision	Datetime	Status	ChangeLog Entry
0	2020-05-25 23:49:57	ID requested
⏵ 1	2022-10-30 11:52:48	announced
2	2023-11-14 08:50:53	announced	2023-11-14: Updated project metadata.

submitter keyword: cardiomyopathy

cell biology

metabolism

proteomics

stem cells

ChristofLenz
contact affiliation	Institute of Clinical Chemistry, University Medical Center Goettingen
contact email	christof.lenz@mpibpc.mpg.de
lab head
ChristofLenz
contact affiliation	Max Planck Institute for Biophysical Chemistry
contact email	christof.lenz@mpibpc.mpg.de
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2022/10/PXD019380

PRIDE project URI

• PRIDE
  1. PXD019380
     1. Label: PRIDE project
     2. Name: The Caveolin3 complex stabilizes functional surface expression of the Lactate-Proton Shuttle McT1 but not the sodium channel Nav1.5 in cardiomyocytes