PXD019212-1

PXD019212 is an original dataset announced via ProteomeXchange.

Title	Serum proteome profiling provides a deep understanding of the “gut–liver axis” in relation to liver injury and regeneration
Description	The gut–liver axis is one of the major contributors to the transport of products from the intestine or intestinal microbes with the progression of liver regeneration. However, the influence of proteins from the hepatic portal vein (HPV), the bridge of enterohepatic circulation, on liver regeneration is unclear. For first time, we applied a quantitative proteomics approach to characterize the molecular pathology of the HPV sera of mice with antibiotic-induced intestinal flora disorder during acute liver injury. The biological processes of lipid metabolism and wound healing were enriched in the HPV of mice with intestinal flora disorder, whereas energy metabolism, liver regeneration, and cytoskeletal processes were downregulated. Moreover, 95 and 35 proteins potentially promoting or inhibiting liver regeneration, respectively, were identified in HPV serum. Our findings will be beneficial to liver donors during liver transplantation.
HostingRepository	iProX
AnnounceDate	2020-05-15
AnnouncementXML	Submission_2023-08-27_20:55:15.432.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Ling Leng
SpeciesList	scientific name: Mus musculus; NCBI TaxID: 10090;
ModificationList	No PTMs are included in the dataset
Instrument	Q Exactive HF

Revision	Datetime	Status	ChangeLog Entry
0	2020-05-14 19:06:55	ID requested
⏵ 1	2023-08-27 20:55:16	announced

Leng L, Ma J, Lv L, Gao D, Li M, Wang Y, Zhu Y, Serum proteome profiling provides a deep understanding of the 'gut-liver axis' in relation to liver injury and regeneration. Acta Biochim Biophys Sin (Shanghai), 53(3):372-380(2021) [pubmed]

submitter keyword: Gut–liver axis, intestinal flora disorder, hepatic portal vein serum, liver regeneration, proteomics

Yunping Zhu
contact affiliation	National Center for Protein Sciences (Beijing).
contact email	zhuyunping@gmail.com
lab head
Ling Leng
contact affiliation	Peking Union Medical College Hospital
contact email	zhenlinger@126.com
dataset submitter

iProX dataset URI