PXD019209 is an
original dataset announced via ProteomeXchange.
Dataset Summary
Title | WDR5 protein interactions at the WIN-site |
Description | The WIN site of WDR5 is a druggable pocket that impairs WDR5 protein function and carries therapeutic potential for treating cancer. This study evaluates the protein interactions affected by small molecule blockade of this surface on WDR5. Inhibited and uninhibited WDR5-containing complexes from HEK293 cells were quantitatively compared by SILAC-based proteomics. Of the high confidence proteins affected by this inhibition, one protein, PDPK1, was investigated further by mass spectrometry for identification of post translational modifications that could influence binding to WDR5. |
HostingRepository | PRIDE |
AnnounceDate | 2021-01-25 |
AnnouncementXML | Submission_2021-01-24_22:53:16.xml |
DigitalObjectIdentifier | |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | Kristie Lindsey Rose |
SpeciesList | scientific name: Homo sapiens (Human); NCBI TaxID: 9606; |
ModificationList | monoacetylated residue; isotope labeled residue; monohydroxylated residue; iodoacetamide derivatized residue |
Instrument | Q Exactive Plus |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
0 | 2020-05-14 18:58:36 | ID requested | |
⏵ 1 | 2021-01-24 22:53:16 | announced | |
2 | 2021-01-24 23:03:08 | announced | 2021-01-25: Updated publication reference for PubMed record(s): 33472061. |
Publication List
Dataset with its publication pending |
Keyword List
submitter keyword: WDR5, chromatin, signaling, SILAC, immunoprecipitation |
Contact List
Kristie Lindsey Rose |
contact affiliation | Vanderbilt Proteomics Core |
contact email | kristie.rose@vanderbilt.edu |
lab head | |
Kristie Lindsey Rose |
contact affiliation | Vanderbilt university |
contact email | kristie.rose@vanderbilt.edu |
dataset submitter | |
Full Dataset Link List
Dataset FTP location
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PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD019209
- Label: PRIDE project
- Name: WDR5 protein interactions at the WIN-site