PXD019149-1

PXD019149 is an original dataset announced via ProteomeXchange.

Title	Extensive transfer of genes for edible seaweed digestion from marine to human gut bacteria
Description	Humans harbor numerous species of colonic bacteria that digest the fiber polysaccharides in commonly consumed terrestrial plants. More recently in history, regional populations have consumed edible seaweeds (macroalgae) containing unique polysaccharides. However, it remains unclear how extensively gut bacteria have adapted to digest these novel nutrients. Here, we show that the ability of gut bacteria to digest seaweed polysaccharides is considerably more pervasive than previously appreciated. Using culture-based approaches, we show that known Bacteroides genes involved in seaweed degradation have mobilized into many members of this genus. We also identify new marine bacteria-derived genes, and their corresponding mobile DNA elements, that are involved in degrading several seaweed polysaccharides. Some of these new genes reside in gut-resident, Gram-positive Firmicutes, for which phylogenetic analysis suggests an origin in the Epulopiscium gut symbionts of marine fishes. Our results are important for understanding the metabolic plasticity of the human gut microbiome, the global exchange of genes in the context of dietary selective pressures and identifying new functions that can be introduced or engineered to design and fill orthogonal niches for a future generation of engineered probiotics.
HostingRepository	PRIDE
AnnounceDate	2021-11-04
AnnouncementXML	Submission_2021-11-04_00:29:23.544.xml
DigitalObjectIdentifier	https://dx.doi.org/10.6019/PXD019149
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Supported dataset by repository
PrimarySubmitter	Stephanie Markert
SpeciesList	scientific name: Bacteroides thetaiotaomicron; NCBI TaxID: 818;
ModificationList	Oxidation
Instrument	LTQ Orbitrap Classic

Revision	Datetime	Status	ChangeLog Entry
0	2020-05-12 22:34:19	ID requested
⏵ 1	2021-11-04 00:29:23	announced

Dataset with its publication pending

submitter keyword: gut bacteria, seaweed, polysaccharides, Bateroides, microbiome

Stephanie Markert
contact affiliation	Universität Greifswald Institut für Pharmazie, AG Pharmazeutische Biotechnologie Greifswald, Germany
contact email	stephanie.markert@uni-greifswald.de
lab head
Stephanie Markert
contact affiliation	University of Greifswald
contact email	stephanie.markert@uni-greifswald.de
dataset submitter

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PRIDE project URI

• PRIDE
  1. PXD019149
     1. Label: PRIDE project
     2. Name: Extensive transfer of genes for edible seaweed digestion from marine to human gut bacteria