PXD019087-3

PXD019087 is an original dataset announced via ProteomeXchange.

Title	TEX15 is an essential executor of MIWI2-directed transposon DNA methylation and silencing.
Description	The PIWI protein MIWI2 and its associated PIWI-interacting RNAs (piRNAs) instruct DNA methylation of young active transposable elements (TEs) in the male germline. Here we show that MIWI2 associates with TEX15 in foetal gonocytes. TEX15 is predominantly a nuclear protein that is not required for piRNA biogenesis but is essential for piRNA-directed TE de novo methylation and silencing. In summary, TEX15 is an essential executor of mammalian piRNA-directed DNA methylation.
HostingRepository	PRIDE
AnnounceDate	2024-10-22
AnnouncementXML	Submission_2024-10-22_05:07:25.160.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Tania Auchynnikava
SpeciesList	scientific name: Mus musculus (Mouse); NCBI TaxID: 10090;
ModificationList	No PTMs are included in the dataset
Instrument	Orbitrap Fusion Lumos

Revision	Datetime	Status	ChangeLog Entry
0	2020-05-11 07:51:27	ID requested
1	2020-06-17 22:17:38	announced
2	2020-08-11 04:43:54	announced	2020-08-11: Updated publication reference for PubMed record(s): 32719317.
⏵ 3	2024-10-22 05:07:26	announced	2024-10-22: Updated project metadata.

10.1038/s41467-020-17372-5;

Sch, ö, pp T, Zoch A, Berrens RV, Auchynnikava T, Kabayama Y, Vasiliauskait, ė L, Rappsilber J, Allshire RC, O'Carroll D, TEX15 is an essential executor of MIWI2-directed transposon DNA methylation and silencing. Nat Commun, 11(1):3739(2020) [pubmed]

submitter keyword: Mouse transposon silencing

Donal O'Carroll
contact affiliation	1. MRC Centre for Regenerative Medicine, Institute for Stem Cell Research, School of Biological Sciences, University of Edinburgh, 5 Little France Drive, Edinburgh, EH16 4UU, UK. 2. Wellcome Centre for Cell Biology, University of Edinburgh, Edinburgh, EH9 3BF, UK.
contact email	donal.ocarroll@ed.ac.uk
lab head
Tania Auchynnikava
contact affiliation	WCB, The University of Edinburgh
contact email	T.Auchynnikava@ed.ac.uk
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2020/06/PXD019087

PRIDE project URI

• PRIDE
  1. PXD019087
     1. Label: PRIDE project
     2. Name: TEX15 is an essential executor of MIWI2-directed transposon DNA methylation and silencing.