PXD019014-1

PXD019014 is an original dataset announced via ProteomeXchange.

Title	Identification of serum-based biomarkers in oral cancer among tobacco users
Description	Oral cancer is the leading cancer worldwide with significant morbidity and mortality rate. Use of tobacco in form of both chewing and smoking have been known as major risk factors along with alcohol and HPV infection. Despite such knowledge, there are yet no proper screening strategy employed for screening of oral cancer at early stage. In this study, we employed TMT-based comparison of proteins from serum samples from healthy volunteers and OSCC patients with chewing and smoking habits. The data has been acquired in triplicate where we have used multiple fractionation strategies such as bRPLC and SCX-based fractionation. The candidate proteins identified at discovery phase were further validated using ELISA.
HostingRepository	PRIDE
AnnounceDate	2026-04-27
AnnouncementXML	Submission_2026-04-26_19:29:41.973.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Keshava Prasad T. S.
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: NEWT:9606;
ModificationList	TMT6plex-126 reporter+balance reagent acylated residue; monohydroxylated residue; acetylated residue; iodoacetamide derivatized residue
Instrument	Orbitrap Fusion

Revision	Datetime	Status	ChangeLog Entry
0	2020-05-06 17:47:31	ID requested
⏵ 1	2026-04-26 19:29:43	announced

10.3233/cbm-203077;

Mohanty V, Subbannayya Y, Patil S, Abdulla R, Ganesh MS, Pal A, Ray JG, Sidransky D, Gowda H, Prasad TSK, Chatterjee A, Molecular alterations in oral cancer between tobacco chewers and smokers using serum proteomics. Cancer Biomark, 31(4):361-373(2021) [pubmed]

submitter keyword: OSCC, Serum proteomics, smoke, Tobacco, Mass spectrometry

T. S. Keshava Prasad
contact affiliation	Center for Systems Biology and Molecular Medicine, Yenepoya Research Centre, Yenepoya (Deemed to be University), University Road, Deralakatte, Mangalore 575018, India
contact email	keshav@yenepoya.edu.in
lab head
Keshava Prasad T. S.
contact affiliation	Professor and Deputy Director, Center for Systems Biology and Molecular Medicine, Yenepoya Research Centre, Yenepoya (Deemed to be University), Mangalore, India
contact email	keshav@ibioinformatics.org
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/04/PXD019014

PRIDE project URI

• PRIDE
  1. PXD019014
     1. Label: PRIDE project
     2. Name: Identification of serum-based biomarkers in oral cancer among tobacco users